TY - JOUR
T1 - Recent developments in the role of reactive oxygen species in allergic asthma
AU - Qu, Jingjing
AU - Li, Yuanyuan
AU - Zhong, Wen
AU - Gao, Peisong
AU - Hu, Chengping
N1 - Publisher Copyright:
© Journal of Thoracic Disease.
PY - 2017
Y1 - 2017
N2 - Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway inflammation. Accordingly, the unique role of reactive oxygen species (ROS) had been identified as a main reason for this respiratory inflammation. Many studies have shown that inhalation of different allergens can promote ROS generation. Recent studies have demonstrated that several pro-inflammatory mediators are responsible for the development of allergic asthma. Among these mediators, endogenous or exogenous ROS are responsible for the airway inflammation of allergic asthma. Furthermore, several inflammatory cells induce ROS and allergic asthma development. Airway inflammation, airway hyper-responsiveness, tissue injury, and remodeling can be induced by excessive ROS production in animal models. Based on investigations of allergic asthma and ROS formation mechanisms, we have identified several novel anti-inflammatory therapeutic treatments. This review describes the recent data linking ROS to the pathogenesis of allergic asthma.
AB - Allergic asthma has a global prevalence, morbidity, and mortality. Many environmental factors, such as pollutants and allergens, are highly relevant to allergic asthma. The most important pathological symptom of allergic asthma is airway inflammation. Accordingly, the unique role of reactive oxygen species (ROS) had been identified as a main reason for this respiratory inflammation. Many studies have shown that inhalation of different allergens can promote ROS generation. Recent studies have demonstrated that several pro-inflammatory mediators are responsible for the development of allergic asthma. Among these mediators, endogenous or exogenous ROS are responsible for the airway inflammation of allergic asthma. Furthermore, several inflammatory cells induce ROS and allergic asthma development. Airway inflammation, airway hyper-responsiveness, tissue injury, and remodeling can be induced by excessive ROS production in animal models. Based on investigations of allergic asthma and ROS formation mechanisms, we have identified several novel anti-inflammatory therapeutic treatments. This review describes the recent data linking ROS to the pathogenesis of allergic asthma.
KW - Allergic asthma
KW - Antioxidants
KW - Reactive oxygen species (ROS)
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U2 - 10.21037/jtd.2017.01.05
DO - 10.21037/jtd.2017.01.05
M3 - Review article
C2 - 28203435
AN - SCOPUS:85010332736
SN - 2072-1439
VL - 9
SP - E32-E43
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
IS - 1
ER -