Recent developments in HLA-haploidentical transplantations

Research output: Contribution to journalReview articlepeer-review

Abstract

While allogeneic hematopoietic stem cell transplantations have a curative potential, several patients with hematologic malignancies cannot avail themselves of this therapeutic option due to lack of matched donor availability. Although HLA-haploidentical transplantations were previously associated with poor outcomes, recent evidence with use of post transplantation cyclophosphamide indicate improved safety and efficacy. The following paper discusses the most recent developments in this area.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalBest Practice and Research: Clinical Haematology
Volume28
Issue number2-3
DOIs
StatePublished - Jun 1 2015

Keywords

  • Acute myeloid leukemia
  • Cyclophosphamide
  • Graft versus host disease
  • HLA-haploidentical transplantation
  • Matched related donor
  • Matched unrelated donor
  • Mismatched unrelated donor
  • Relapse

ASJC Scopus subject areas

  • Oncology
  • Clinical Biochemistry

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