Recent developments in DNA topoisomerase II structure and mechanism

James M Berger, James C. Wang

Research output: Contribution to journalArticle

Abstract

Type II DNA topoisomerases are enzymes that are capable of transporting one duplex DNA through another. Recent experimental results, including the structure of a fragment of yeast topoisomerase II, have provided new insights into the mechanism of the strand passage reaction. Other results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.

Original languageEnglish (US)
Pages (from-to)84-90
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume6
Issue number1
DOIs
StatePublished - Feb 1996
Externally publishedYes

Fingerprint

Type II DNA Topoisomerase
DNA Breaks
Adenosine Triphosphate
Yeasts
DNA
Enzymes

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

Cite this

Recent developments in DNA topoisomerase II structure and mechanism. / Berger, James M; Wang, James C.

In: Current Opinion in Structural Biology, Vol. 6, No. 1, 02.1996, p. 84-90.

Research output: Contribution to journalArticle

@article{40b2c3115b9a42d99025314a305b64f5,
title = "Recent developments in DNA topoisomerase II structure and mechanism",
abstract = "Type II DNA topoisomerases are enzymes that are capable of transporting one duplex DNA through another. Recent experimental results, including the structure of a fragment of yeast topoisomerase II, have provided new insights into the mechanism of the strand passage reaction. Other results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.",
author = "Berger, {James M} and Wang, {James C.}",
year = "1996",
month = "2",
doi = "10.1016/S0959-440X(96)80099-6",
language = "English (US)",
volume = "6",
pages = "84--90",
journal = "Current Opinion in Structural Biology",
issn = "0959-440X",
publisher = "Elsevier Limited",
number = "1",

}

TY - JOUR

T1 - Recent developments in DNA topoisomerase II structure and mechanism

AU - Berger, James M

AU - Wang, James C.

PY - 1996/2

Y1 - 1996/2

N2 - Type II DNA topoisomerases are enzymes that are capable of transporting one duplex DNA through another. Recent experimental results, including the structure of a fragment of yeast topoisomerase II, have provided new insights into the mechanism of the strand passage reaction. Other results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.

AB - Type II DNA topoisomerases are enzymes that are capable of transporting one duplex DNA through another. Recent experimental results, including the structure of a fragment of yeast topoisomerase II, have provided new insights into the mechanism of the strand passage reaction. Other results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.

UR - http://www.scopus.com/inward/record.url?scp=0029911698&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029911698&partnerID=8YFLogxK

U2 - 10.1016/S0959-440X(96)80099-6

DO - 10.1016/S0959-440X(96)80099-6

M3 - Article

C2 - 8696977

AN - SCOPUS:0029911698

VL - 6

SP - 84

EP - 90

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

SN - 0959-440X

IS - 1

ER -