TY - JOUR
T1 - Recent Developments and Future Challenges on Imaging for Stem Cell Research
AU - Fu, Yingli
AU - Kedziorek, Dorota
AU - Kraitchman, Dara L.
N1 - Funding Information:
Acknowledgments This work was supported by grants from Siemens Medical Systems, the National Institutes of Health (R21HL89029), and the Maryland Stem Cell Research Fund (2008-MSCRFII-0399). Research materials were provided from Boston Scientific Corp, Inc. The authors thank Brad Barnett, Dr. Jeff W. M. Bulte, and Dr. Aravind Arepally for assistance with the microencapsulation design and Drs. Steve Shea, Tina Ehtiati, Ron Ouwerwerk, and Robert Krieg for assistance with the medical imaging.
PY - 2010/2
Y1 - 2010/2
N2 - As clinical trials with stem cells for cardiac regenerative therapy move forward, advances in imaging equipment and technique offer powerful methods to evaluate therapeutic efficacy. Methodologies to label stem cells for tracking continue to expand. Non-invasive imaging offers the potential to better understand the interaction of exogenous stem cells with the host to answer questions such as the best cell type(s), timing of delivery, dose, and delivery route. If successful, these techniques may enable individually tailored dosing of stem cell therapeutics. However, techniques that are suitable for animal models of cardiac disease may have hurdles to clinical translation beyond simple biocompatibility issues. Challenges include the high cost of advanced imaging techniques, applicability in acute ischemic disease, and regulatory approval. In this review, we will cover some new imaging techniques and labeling strategies and assess the obstacles to clinical adoption.
AB - As clinical trials with stem cells for cardiac regenerative therapy move forward, advances in imaging equipment and technique offer powerful methods to evaluate therapeutic efficacy. Methodologies to label stem cells for tracking continue to expand. Non-invasive imaging offers the potential to better understand the interaction of exogenous stem cells with the host to answer questions such as the best cell type(s), timing of delivery, dose, and delivery route. If successful, these techniques may enable individually tailored dosing of stem cell therapeutics. However, techniques that are suitable for animal models of cardiac disease may have hurdles to clinical translation beyond simple biocompatibility issues. Challenges include the high cost of advanced imaging techniques, applicability in acute ischemic disease, and regulatory approval. In this review, we will cover some new imaging techniques and labeling strategies and assess the obstacles to clinical adoption.
KW - CT Imaging
KW - Magnetic Resonance Imaging
KW - Radionuclide Imaging
KW - Reporter Gene Imaging
KW - Stem Cells
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U2 - 10.1007/s12265-009-9158-x
DO - 10.1007/s12265-009-9158-x
M3 - Review article
C2 - 20376306
AN - SCOPUS:75949105879
SN - 1937-5387
VL - 3
SP - 24
EP - 29
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 1
ER -