TY - JOUR
T1 - Recent Advances in Tissue Engineering Strategies for the Treatment of Joint Damage
AU - Stephenson, Makeda K.
AU - Farris, Ashley L.
AU - Grayson, Warren L
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Purpose of Review: While the clinical potential of tissue engineering for treating joint damage has yet to be realized, research and commercialization efforts in the field are geared towards overcoming major obstacles to clinical translation, as well as towards achieving engineered grafts that recapitulate the unique structures, function, and physiology of the joint. In this review, we describe recent advances in technologies aimed at obtaining biomaterials, stem cells, and bioreactors that will enable the development of effective tissue-engineered treatments for repairing joint damage. Recent Findings: 3D printing of scaffolds is aimed at improving the mechanical structure and microenvironment necessary for bone regeneration within a damaged joint. Advances in our understanding of stem cell biology and cell manufacturing processes are informing translational strategies for the therapeutic use of allogeneic and autologous cells. Finally, bioreactors used in combination with cells and biomaterials are promising strategies for generating large tissue grafts for repairing damaged tissues in pre-clinical models. Summary: Together, these advances along with ongoing research directions are making tissue engineering increasingly viable for the treatment of joint damage.
AB - Purpose of Review: While the clinical potential of tissue engineering for treating joint damage has yet to be realized, research and commercialization efforts in the field are geared towards overcoming major obstacles to clinical translation, as well as towards achieving engineered grafts that recapitulate the unique structures, function, and physiology of the joint. In this review, we describe recent advances in technologies aimed at obtaining biomaterials, stem cells, and bioreactors that will enable the development of effective tissue-engineered treatments for repairing joint damage. Recent Findings: 3D printing of scaffolds is aimed at improving the mechanical structure and microenvironment necessary for bone regeneration within a damaged joint. Advances in our understanding of stem cell biology and cell manufacturing processes are informing translational strategies for the therapeutic use of allogeneic and autologous cells. Finally, bioreactors used in combination with cells and biomaterials are promising strategies for generating large tissue grafts for repairing damaged tissues in pre-clinical models. Summary: Together, these advances along with ongoing research directions are making tissue engineering increasingly viable for the treatment of joint damage.
KW - Additive manufacturing
KW - Bioreactors
KW - Bone tissue engineering
KW - Design control
KW - Joint disease
KW - Stem cell manufacturing
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U2 - 10.1007/s11926-017-0671-7
DO - 10.1007/s11926-017-0671-7
M3 - Review article
C2 - 28718059
AN - SCOPUS:85024380740
SN - 1523-3774
VL - 19
JO - Current Rheumatology Reports
JF - Current Rheumatology Reports
IS - 8
M1 - 44
ER -