Recent advances in the molecular biology of metazoan polyamine transport

R. Poulin, R. A. Casero, D. Soulet

Research output: Contribution to journalReview articlepeer-review

Abstract

Very limited molecular knowledge exists about the identity and protein components of the ubiquitous polyamine transporters found in animal cells. However, a number of reports have been published over the last 5 years on potential candidates for metazoan polyamine permeases. We review the available evidence on these putative polyamine permeases, as well as establish a useful «identikit picture» of the general polyamine transport system, based on its properties as found in a wide spectrum of mammalian cells. Any molecular candidate encoding a putative «general» polyamine permease should fit that provided portrait. The current models proposed for the mechanism of polyamine internalization in mammalian cells are also briefly reviewed.

Original languageEnglish (US)
Pages (from-to)711-723
Number of pages13
JournalAmino Acids
Volume42
Issue number2-3
DOIs
StatePublished - Feb 2012

Keywords

  • DNA cloning
  • Membrane transport
  • Permeases
  • Polyamines
  • Vesicular transport

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Clinical Biochemistry

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