Recent advances in the genetics of epilepsy: Insights from human and animal studies

Asuri N. Prasad, Chitra Prasad, Carl E. Stafstrom

Research output: Contribution to journalReview articlepeer-review

Abstract

Progress in understanding the genetics of epilepsy is proceeding at a dizzying pace. Due in large part to rapid progress in molecular genetics, gene defects underlying many of the inherited epilepsies have been mapped, and several more are likely to be added each year. In this review, we summarize the available information on the genetic basis of human epilepsies and epilepsy syndromes, and correlate these advances with rapidly expanding information about the mechanisms of epilepsy gained from both spontaneous and transgenic animal models. We also provide practical suggestions for clinicians confronted with families in which multiple members are afflicted with epilepsy.

Original languageEnglish (US)
Pages (from-to)1329-1352
Number of pages24
JournalEpilepsia
Volume40
Issue number10
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Animal models
  • Epilepsy
  • Genetics
  • Human
  • Pathophysiology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Recent advances in the genetics of epilepsy: Insights from human and animal studies'. Together they form a unique fingerprint.

Cite this