Recent advances in the discovery of Src kinase inhibitors

Keykavous Parang, Gongqin Sun

Research output: Contribution to journalArticle

Abstract

Src family kinases are involved in the regulation of a wide variety of normal cellular signal transduction pathways, such as cell growth, differentiation, survival, adhesion and migration. Considerable evidence implicates elevated expression and/or activity of Src kinases in many human cancers, osteoporosis, cardiovascular disorders and immune system dysfunction; thus, this family of protein tyrosine kinases now exists as intriguing targets for both basic research and drug discovery. Herein, a number of examples of currently developed Src family kinase inhibitors in selected patents from 2002 - 2005 will be described. Special attention will be made to the chemical diversity of ATP binding site inhibitors, potency, selectivity and therapeutic application of the compounds.

Original languageEnglish (US)
Pages (from-to)1183-1207
Number of pages25
JournalExpert Opinion on Therapeutic Patents
Volume15
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

src-Family Kinases
bone disease
Patents
basic research
Drug Discovery
Cardiovascular System
patent
Protein-Tyrosine Kinases
Osteoporosis
Cell Differentiation
Immune System
Signal Transduction
cancer
Adenosine Triphosphate
Binding Sites
migration
drug
regulation
Survival
Growth

Keywords

  • Cancer
  • Drug discovery
  • Inhibitor
  • Myocardial infarction
  • Osteoporosis
  • Protein kinase
  • SH2 domain
  • Src
  • Src family kinase
  • Tyrosine kinase

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Law

Cite this

Recent advances in the discovery of Src kinase inhibitors. / Parang, Keykavous; Sun, Gongqin.

In: Expert Opinion on Therapeutic Patents, Vol. 15, No. 9, 09.2005, p. 1183-1207.

Research output: Contribution to journalArticle

Parang, Keykavous ; Sun, Gongqin. / Recent advances in the discovery of Src kinase inhibitors. In: Expert Opinion on Therapeutic Patents. 2005 ; Vol. 15, No. 9. pp. 1183-1207.
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