Recent advances in the discovery of Src kinase inhibitors

Keykavous Parang, Gongqin Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Src family kinases are involved in the regulation of a wide variety of normal cellular signal transduction pathways, such as cell growth, differentiation, survival, adhesion and migration. Considerable evidence implicates elevated expression and/or activity of Src kinases in many human cancers, osteoporosis, cardiovascular disorders and immune system dysfunction; thus, this family of protein tyrosine kinases now exists as intriguing targets for both basic research and drug discovery. Herein, a number of examples of currently developed Src family kinase inhibitors in selected patents from 2002 - 2005 will be described. Special attention will be made to the chemical diversity of ATP binding site inhibitors, potency, selectivity and therapeutic application of the compounds.

Original languageEnglish (US)
Pages (from-to)1183-1207
Number of pages25
JournalExpert Opinion on Therapeutic Patents
Volume15
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Keywords

  • Cancer
  • Drug discovery
  • Inhibitor
  • Myocardial infarction
  • Osteoporosis
  • Protein kinase
  • SH2 domain
  • Src
  • Src family kinase
  • Tyrosine kinase

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Law

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