Recent advances in mucous membrane pemphigoid

Ebenezer Daniel, Jennifer E. Thorne

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: The aim of this article is to review articles on mucous membrane pemphigoid published in the English literature from 2006 to 2007. Recent Findings: The risk of ocular disease among patients with oral only mucous membrane pemphigoid is estimated at 15ĝ€"20% at 5 years. Biopsy with direct immunofluorescent testing is essential to confirm the diagnosis because histopathology even with electron microscopy does not appear to be specific enough to confirm the diagnosis of mucous membrane pemphigoid with consistency. Autoantibodies to IgG and IgG4 appear to be the most common findings observed on direct immunofluorescent testing in patients with mucous membrane pemphigoid. Treatment for mucous membrane pemphigoid typically involves immunosuppressive drugs, including biologic therapy, as well as intravenous immunoglobulin, although results have been mixed and the majority of data reported still are from case series and anecdotal evidence. Summary: Mucous membrane pemphigoid continues to be a potentially life and sight threatening disease. Therapy for this disease continues to show varied results although benefits are clearly seen in some patients. The immunosuppressive drugs used for treating mucous membrane pemphigoid and certain definitive categories of mucous membrane pemphigoid continue to evolve.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalCurrent opinion in ophthalmology
Volume19
Issue number4
DOIs
StatePublished - Jul 1 2008

Keywords

  • Cancer
  • Direct immunofluorescent testing
  • Mucous membrane pemphigoid
  • Ocular cicatricial pemphigoid

ASJC Scopus subject areas

  • Ophthalmology

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