TY - JOUR
T1 - Recent advances in extracellular vesicle research for urological cancers
T2 - From technology to application
AU - Dong, Liang
AU - Zieren, Richard C.
AU - Wang, Yanqing
AU - de Reijke, Theo M.
AU - Xue, Wei
AU - Pienta, Kenneth J.
N1 - Funding Information:
We appreciate Prof. Timothy Phelps for the contribution of beautiful figures for this review. We also appreciate the precious comments from Dr. Sarah R. Amend and Kayla V. Myers. L. D. is supported by Shanghai Natural Science Fund exploration project (17ZR1447400), Shanghai Jiao Tong University medicine-engineering cross project (YG2016QN56) and funding from the key laboratory of specialty fiber optics and optical access network of Shanghai University. R.C.Z. is supported by Stichting Cure for Cancer foundation, Amsterdam, The Netherlands.
Publisher Copyright:
© 2019
PY - 2019/4
Y1 - 2019/4
N2 - Urological malignancies, including prostate cancer, bladder cancer and kidney cancer, are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bilayer encapsulated particles released by cells into the extracellular space. Since EVs work as a safe way to transport important biological information through the whole body, they are now recognized as an important mechanism of cell–cell communication and have opened a new window for us to gain a better understanding of cancer biology, novel diagnostics, and therapeutic options. In recent years, numerous evolutions in EV technologies and novel biological and clinical findings continue to be reported in the research field of urological cancers. This comprehensive review aims to give an update of recent advances in EV technologies and summarize the state-of-the-art knowledge of EVs related to prostate cancer, bladder cancer and kidney cancer, particularly focusing on the potential of EV as biomarkers and their biological roles in promoting cancer and metastasis.
AB - Urological malignancies, including prostate cancer, bladder cancer and kidney cancer, are major causes of morbidity and mortality worldwide. Because of the high incidence, diversity in biology, and especially direct interaction with urine, urological cancers are an important resource for both scientists and clinicians for novel diagnostic and therapeutic discovery. Extracellular vesicles (EVs) are lipid bilayer encapsulated particles released by cells into the extracellular space. Since EVs work as a safe way to transport important biological information through the whole body, they are now recognized as an important mechanism of cell–cell communication and have opened a new window for us to gain a better understanding of cancer biology, novel diagnostics, and therapeutic options. In recent years, numerous evolutions in EV technologies and novel biological and clinical findings continue to be reported in the research field of urological cancers. This comprehensive review aims to give an update of recent advances in EV technologies and summarize the state-of-the-art knowledge of EVs related to prostate cancer, bladder cancer and kidney cancer, particularly focusing on the potential of EV as biomarkers and their biological roles in promoting cancer and metastasis.
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U2 - 10.1016/j.bbcan.2019.01.008
DO - 10.1016/j.bbcan.2019.01.008
M3 - Review article
C2 - 30738098
AN - SCOPUS:85062983363
SN - 0304-419X
VL - 1871
SP - 342
EP - 360
JO - Biochimica et Biophysica Acta - Reviews on Cancer
JF - Biochimica et Biophysica Acta - Reviews on Cancer
IS - 2
ER -