Recent advances in drug repositioning for the discovery of new anticancer drugs

Joong Sup Shim, Jun O. Liu

Research output: Contribution to journalReview article

Abstract

Drug repositioning (also referred to as drug repurposing), the process of finding new uses of existing drugs, has been gaining popularity in recent years. The availability of several established clinical drug libraries and rapid advances in disease biology, genomics and bioinformatics has accelerated the pace of both activity-based and in silico drug repositioning. Drug repositioning has attracted particular attention from the communities engaged in anticancer drug discovery due to the combination of great demand for new anticancer drugs and the availability of a wide variety of cell-and target-based screening assays. With the successful clinical introduction of a number of non-cancer drugs for cancer treatment, drug repositioning now became a powerful alternative strategy to discover and develop novel anticancer drug candidates from the existing drug space. In this review, recent successful examples of drug repositioning for anticancer drug discovery from non-cancer drugs will be discussed.

Original languageEnglish (US)
Pages (from-to)654-663
Number of pages10
JournalInternational Journal of Biological Sciences
Volume10
Issue number7
DOIs
StatePublished - Jun 10 2014

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Keywords

  • Angiogenesis
  • Cancer
  • Drug discovery
  • Drug library
  • Drug repositioning
  • Drug screening

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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