Recapitulation of molecular regulators of nuclear motion during cell migration

Alexandra Sneider, Jungwon Hah, Denis Wirtz, Dong Hwee Kim

Research output: Contribution to journalArticle

Abstract

Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

Original languageEnglish (US)
Pages (from-to)50-62
Number of pages13
JournalCell adhesion & migration
Volume13
Issue number1
DOIs
StatePublished - Dec 1 2019

Keywords

  • Cell migration
  • Cytoskeleton
  • LINC complex
  • Nuclear mechanics

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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