Recapitulation of molecular regulators of nuclear motion during cell migration

Alexandra Sneider; Jungwon Hah; Denis Wirtz; Dong Hwee Kim

doi:10.1080/19336918.2018.1506654

Recapitulation of molecular regulators of nuclear motion during cell migration

Alexandra Sneider, Jungwon Hah, Denis Wirtz, Dong Hwee Kim

Whiting School of Engineering

Research output: Contribution to journal › Review article › peer-review

6 Scopus citations

Abstract

Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

Original language	English (US)
Pages (from-to)	50-62
Number of pages	13
Journal	Cell Adhesion and Migration
Volume	13
Issue number	1
DOIs	https://doi.org/10.1080/19336918.2018.1506654
State	Published - Jan 1 2019

Keywords

Cell migration
Cytoskeleton
LINC complex
Nuclear mechanics

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Cell Biology

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10.1080/19336918.2018.1506654

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title = "Recapitulation of molecular regulators of nuclear motion during cell migration",

abstract = "Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.",

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author = "Alexandra Sneider and Jungwon Hah and Denis Wirtz and Kim, {Dong Hwee}",

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AU - Sneider, Alexandra

AU - Hah, Jungwon

AU - Wirtz, Denis

AU - Kim, Dong Hwee

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Y1 - 2019/1/1

N2 - Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

AB - Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.

KW - Cell migration

KW - Cytoskeleton

KW - LINC complex

KW - Nuclear mechanics

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Recapitulation of molecular regulators of nuclear motion during cell migration

Abstract

Keywords

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