Reassessment of the morphological continuum of cervical intraepithelial lesions: does it reflect different stages in the progression to cervical carcinoma?

N. B. Kiviat, C. W. Critchlow, R. J. Kurman

Research output: Contribution to journalReview article


Currently used histological and cytological classification systems for cervical lesions are reviewed. These suffer from poor inter- and intra-observer reproducibility, and do not allow accurate identification of which mild lesions will progress towards cancer. The Bethesda classification system is described and it is postulated that low-grade and high-grade squamous intraepithelial lesions might represent distinct entities with different potential for progression rather than necessary stages of a continuum leading to cervical cancer. Improved understanding of the etiological role of HPV types in cervical cancer and of the natural history of low- and high-grade intraepithelial lesions might result in more suitable clinical treatment of low-grade lesions.

Original languageEnglish (US)
Pages (from-to)59-66
Number of pages8
JournalIARC scientific publications
Issue number119
StatePublished - 1992
Externally publishedYes


ASJC Scopus subject areas

  • Medicine(all)

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