Abstract
Currently used histological and cytological classification systems for cervical lesions are reviewed. These suffer from poor inter- and intra-observer reproducibility, and do not allow accurate identification of which mild lesions will progress towards cancer. The Bethesda classification system is described and it is postulated that low-grade and high-grade squamous intraepithelial lesions might represent distinct entities with different potential for progression rather than necessary stages of a continuum leading to cervical cancer. Improved understanding of the etiological role of HPV types in cervical cancer and of the natural history of low- and high-grade intraepithelial lesions might result in more suitable clinical treatment of low-grade lesions.
Original language | English (US) |
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Pages (from-to) | 59-66 |
Number of pages | 8 |
Journal | IARC scientific publications |
Issue number | 119 |
State | Published - 1992 |
Externally published | Yes |
ASJC Scopus subject areas
- General Medicine