Rearranged β t cell receptor genes in a helper t cell clone specific for lysozyme: No correlation between Vβ and MHC restriction

Joan Goverman, Karyl Minard, Nilabh Shastri, Tim Hunkapiller, Dan Hansburg, Eli Sercarz, Leroy Hood

Research output: Contribution to journalArticlepeer-review

Abstract

The helper T cell clone 3H.25 is specific for hen egg white lysozyme and the class II MHC molecule I-Ab. This TH cell has three rearrangements in the β-chain gene family-a Vβ-Dβ-Jpβ1 and a Dβ2-Jβ2 rearrangement on one homolog and a Dβ1-Jβ2 rearrangement on the other. These observations demonstrate that this functional T lymphocyte expresses only a single Vβ gene segment and, accordingly, exhibits allelic exclusion of β-chain gene expression. The rearranged 3H.25 Vβ gene segment is the same as that expressed in a T helper cell specific for cytochrome c and an I-Ek MHC molecule. Thus, there is no simple correlation between the Vβ gene segment and antigen specificity or MHC restriction.

Original languageEnglish (US)
Pages (from-to)859-867
Number of pages9
JournalCell
Volume40
Issue number4
DOIs
StatePublished - Apr 1985
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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