Real-time single-heartbeat fast strain-encoded imaging of right ventricular regional function: Normal versus chronic pulmonary hypertension

Monda L. Shehata, Tamer A. Basha, Wahid H. Tantawy, Joao A. Lima, Jens Vogel-Claussen, David A. Bluemke, Paul M. Hassoun, Nael F. Osman

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with pulmonary hypertension and suspected right ventricular (RV) dysfunction often have dyspnea at rest, making reliable assessment of RV function using traditional breath-holding methods difficult to perform. Using single-heartbeat fast strain encoding (Fast-SENC) imaging, peak systolic RV circumferential and longitudinal strains were measured in 11 healthy volunteers and 11 pulmonary hypertension patients. Fast-SENC RV longitudinal strain and circumferential strain measurements were compared to conventional SENC and MR tagging, respectively. Fast-SENC circumferential and longitudinal RV shortening correlated closely with SENC measurements (r = 0.86, r = 0.90, P < 0.001 for all). Circumferential strain, by conventional tagging, showed moderate correlation with Fast-SENC in pulmonary hypertension patients only (r = 0.5, P = 0.003). A nonuniform pattern of RV circumferential shortening was depicted in both groups. Peak systolic circumferential strain was significantly reduced at the basal RV in pulmonary hypertension patients (-18.06 ± 3.3 versus -21.9 ± 1.9, P < 0.01) compared to normal individuals, while peak systolic longitudinal strain was significantly reduced at all levels (P < 0.01 for all). Fast-SENC is a feasible and reliable technique for rapid quantification of RV regional function in a single-heartbeat acquisition. Information derived from Fast-SENC allows characterization of RV regional function in normal individuals and in pulmonary hypertension patients.

Original languageEnglish (US)
Pages (from-to)98-106
Number of pages9
JournalMagnetic resonance in medicine
Volume64
Issue number1
DOIs
StatePublished - Jul 2010

Keywords

  • Fast-SENC
  • Pulmonary hypertension
  • Right ventricle
  • SENC
  • Strain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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