Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system

Nathanael Kuo, Hyun Jae Kang, Danny Y Song, Jin U. Kang, Emad Boctor

Research output: Contribution to journalArticle

Abstract

Prostate brachytherapy is a popular prostate cancer treatment option that involves the permanent implantation of radioactive seeds into the prostate. However, contemporary brachytherapy procedure is limited by the lack of an imaging system that can provide real-time seed-position feedback. While many other imaging systems have been proposed, photoacoustic imaging has emerged as a potential ideal modality to address this need, since it could easily be incorporated into the current ultrasound system used in the operating room. We present such a photoacoustic imaging system built around a clinical ultrasound system to achieve the task of visualizing and localizing seeds. We performed several experiments to analyze the effects of various parameters on the appearance of brachytherapy seeds in photoacoustic images. We also imaged multiple seeds in an ex vivo dog prostate phantom to demonstrate the possibility of using this system in a clinical setting. Although still in its infancy, these initial results of a photoacoustic imaging system for the application of prostate brachytherapy seed localization are highly promising.

Original languageEnglish (US)
Article number066005
JournalJournal of Biomedical Optics
Volume17
Issue number6
DOIs
StatePublished - Jun 2012

Fingerprint

Photoacoustic effect
Seed
seeds
Ultrasonics
Imaging techniques
Imaging systems
Operating rooms
Oncology
dogs
rooms
implantation
cancer
Feedback
Experiments

Keywords

  • Clinical ultrasound
  • Dynamic planning
  • Photoacoustic imaging
  • Prostate brachytherapy

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system. / Kuo, Nathanael; Kang, Hyun Jae; Song, Danny Y; Kang, Jin U.; Boctor, Emad.

In: Journal of Biomedical Optics, Vol. 17, No. 6, 066005, 06.2012.

Research output: Contribution to journalArticle

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