Real-Time Percutaneous Optical Imaging of Anatomical Structures in the Heart Through Blood Using a Catheter-Based Infrared Imaging System

Warren S. Grundfest, Jesus Val-Mejias, Eric Monnet, Bradley Paul Knight, Saman Nazarian, Ronald D. Berger, T. Bruce Ferguson, Mark M. Roden, David Amundson, John Hanlin, Larry Blankenship

Research output: Contribution to journalArticle

Abstract

The ability to optically image structures and instrumentation within the heart during procedures is limited by the presence of blood in the field. The goal of our research was to design, develop, and evaluate technology for a catheter-based optical imaging system that enables intracardiac and intravascular visualization in real time through blood. Based on Mie optical scattering theory, imaging through blood using infrared light was theoretically feasible, but scattering in the near-infrared wavelengths (1100 to 1300 nm) generated substantial noise in the image despite relatively low absorption. Using illumination between 1550 and 1650 nm provided better images, as the effect of scattering is less while the effect of absorption is greater. Absorption losses can be overcome by increasing light intensity. Infrared (IR) transmitting endoscopes were constructed using novel flexible illumination and imaging bundles. Endoscope designs, all 7.5 Fr. in outer diameter, were used to obtain images of the coronary sinus, tricuspid valve, and great vessels in 25 pigs, 16 dogs, 1 calf, and 1 sheep. Imaging was successful in all 43 animals, but the coronary sinus was not always visualizable. After obtaining FDA 510(k) approval, the device was used to acquire images in 50 patients during placement of electrophysiologic leads via right heart catheterization. Clinical experience demonstrates successful visualization in the heart in 45 patients, although coronary sinus images were obtained only in 39 patients. High heart rates, large dilated hearts, and problems with catheter design prevented visualization in all patients. On occasion, it was possible to visualize the tricuspid valve. Infrared endoscopy allows for visualization of intimal surfaces of blood vessels, cardiac chambers, and valves through flowing blood. While technical challenges remain, the feasibility of the approach has been demonstrated.

Original languageEnglish (US)
Pages (from-to)336-341
Number of pages6
JournalSeminars in thoracic and cardiovascular surgery
Volume19
Issue number4
DOIs
StatePublished - Dec 1 2007

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Keywords

  • angioscopy
  • cardiac instrumentation
  • imaging instrumentation
  • infrared imaging

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Grundfest, W. S., Val-Mejias, J., Monnet, E., Knight, B. P., Nazarian, S., Berger, R. D., Ferguson, T. B., Roden, M. M., Amundson, D., Hanlin, J., & Blankenship, L. (2007). Real-Time Percutaneous Optical Imaging of Anatomical Structures in the Heart Through Blood Using a Catheter-Based Infrared Imaging System. Seminars in thoracic and cardiovascular surgery, 19(4), 336-341. https://doi.org/10.1053/j.semtcvs.2007.12.005