Real-time multiple-particle tracking

Applications to drug and gene delivery

Junghae Suh, Michelle Dawson, Justin S Hanes

Research output: Contribution to journalArticle

Abstract

Complex biological environments, such as the cell cytoplasm or the mucus lining the airways of the lungs, can pose significant barriers to efficient therapeutic drug and gene delivery. Biological barriers are particularly important in controlled drug delivery applications that utilize a large carrier particle, such as a liposome or a polymer micro- or nanosphere. The dynamic transport of particulate drug and gene delivery vehicles through these barriers is poorly understood, having been primarily studied with static methods in the past. Recently, the transport of synthetic drug and gene carriers has been investigated quantitatively with real-time particle tracking technology, providing new insight into particle behavior in complex biological environments that is guiding rational improvements in particle design. This review briefly highlights basic principles of particle tracking and its application to elucidate important phenomena that limit effective particulate drug and gene delivery.

Original languageEnglish (US)
Pages (from-to)63-78
Number of pages16
JournalAdvanced Drug Delivery Reviews
Volume57
Issue number1 SPEC. ISS
DOIs
StatePublished - Jan 2 2005

Fingerprint

Pharmaceutical Preparations
Genes
Nanospheres
Synthetic Genes
Drug Carriers
Mucus
Microspheres
Liposomes
Polymers
Cytoplasm
Technology
Lung
Therapeutics

Keywords

  • Diffusion
  • Drug delivery
  • Gene delivery
  • Intracellular
  • Mucus
  • Multiple-particle tracking
  • Rheology
  • Transport

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Real-time multiple-particle tracking : Applications to drug and gene delivery. / Suh, Junghae; Dawson, Michelle; Hanes, Justin S.

In: Advanced Drug Delivery Reviews, Vol. 57, No. 1 SPEC. ISS, 02.01.2005, p. 63-78.

Research output: Contribution to journalArticle

Suh, Junghae ; Dawson, Michelle ; Hanes, Justin S. / Real-time multiple-particle tracking : Applications to drug and gene delivery. In: Advanced Drug Delivery Reviews. 2005 ; Vol. 57, No. 1 SPEC. ISS. pp. 63-78.
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