Real-time monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest in rat

Junyun He, Hongyang Lu, Ruoxian Deng, Leanne Young, Shanbao Tong, Xiaofeng Jia

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac arrest (CA) results in global brain ischemia. To explore the role of cerebral blood flow (CBF) during ischemia, laser speckle contrast imaging (LSCI), a full-field high-resolution optical imaging technique, was used for real-time monitoring of the fluctuations of CBF in a rat model of asphyxial-CA. The temporal changes of CBF were characterized and the relationship between CBF and mean arterial pressure (MAP) was evaluated. Asphyxial-CA led to transient CBF dysregulation, manifested by changes in CBF velocity were significantly impacted by MAP. Hyperemia is aligned with a bolus injection of vecuronium, the first two minutes of asphyxia, the time of epinephrine injection and cardiopulmonary resuscitation, and then lasted for 13 min after the return of spontaneous respiratory (ROSC), followed by hypoperfusion about 55-70% of baseline level no later than 40 min after ROSC. Interestingly, we found that the velocity of venule blood flow increased more than that of the arteriole blood flow during the hyperemia (176% vs 120%). Our study, for the first time, shows real-time CBF changes during and immediately after asphyxial-CA, with high spatial and temporal resolution images. The quantified cerebro-vascular response during the different phases of recovery after CA may underlie the mechanism of injury and recovery after brain ischemia. The study provides a new technique to study the neurovascular coupling and metabolic regulation of CBF after CA.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages6971-6974
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
StatePublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

Fingerprint

Cerebrovascular Circulation
Speckle
Heart Arrest
Rats
Lasers
Blood
Imaging techniques
Monitoring
Blood Flow Velocity
Hyperemia
Brain Ischemia
Arterial Pressure
Brain
Vecuronium Bromide
Injections
Venules
Asphyxia
Resuscitation
Optical Imaging
Cardiopulmonary Resuscitation

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

He, J., Lu, H., Deng, R., Young, L., Tong, S., & Jia, X. (2015). Real-time monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest in rat. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 6971-6974). [7319996] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7319996

Real-time monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest in rat. / He, Junyun; Lu, Hongyang; Deng, Ruoxian; Young, Leanne; Tong, Shanbao; Jia, Xiaofeng.

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. p. 6971-6974 7319996.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

He, J, Lu, H, Deng, R, Young, L, Tong, S & Jia, X 2015, Real-time monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest in rat. in Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. vol. 2015-November, 7319996, Institute of Electrical and Electronics Engineers Inc., pp. 6971-6974, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015, Milan, Italy, 8/25/15. https://doi.org/10.1109/EMBC.2015.7319996
He J, Lu H, Deng R, Young L, Tong S, Jia X. Real-time monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest in rat. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November. Institute of Electrical and Electronics Engineers Inc. 2015. p. 6971-6974. 7319996 https://doi.org/10.1109/EMBC.2015.7319996
He, Junyun ; Lu, Hongyang ; Deng, Ruoxian ; Young, Leanne ; Tong, Shanbao ; Jia, Xiaofeng. / Real-time monitoring of cerebral blood flow by laser speckle contrast imaging after cardiac arrest in rat. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS. Vol. 2015-November Institute of Electrical and Electronics Engineers Inc., 2015. pp. 6971-6974
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