Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery

Kang Zhang, Yong Huang, Gustavo Pradilla, Betty Mae Tyler, Jin U. Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work utilized an ultra-high-speed full-range complex-conjugate-free optical coherence tomography (FD-OCT) system to perform real-time intraoperative imaging to guide two common neurosurgical procedures: the cerebral blood vessel identification and the brain tumor resection. The cerebral blood vessel identification experiment is conducted ex vivo on human cadaver specimen. Specific cerebral arteries and veins in different positions of the specimen are visualized and the spatial relations between adjacent vessels are indentified through real-time 3D visualization. The brain tumor resection experiment is conducted in vivo on 9L gliomas established in rat brains. The normal brain-tumor margin can be clearly identified in depth of the tissue from sagittal, coronal and axial slices of the intraoperatively acquired 3D data set. The real-time full-range FD-OCT guided in vivo rat flank tumor resection is also conducted.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7883
DOIs
StatePublished - 2011
EventPhotonic Therapeutics and Diagnostics VII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Other

OtherPhotonic Therapeutics and Diagnostics VII
CountryUnited States
CitySan Francisco, CA
Period1/22/111/24/11

Fingerprint

Vascular Tissue Neoplasms
Neurosurgery
blood vessels
Blood vessels
Brain Neoplasms
brain
Tumors
Brain
tumors
Blood Vessels
Cerebral Veins
rats
Neurosurgical Procedures
Rats
Cerebral Arteries
Optical Coherence Tomography
Cadaver
Glioma
Optical tomography
arteries

Keywords

  • brain tumor resection
  • cerebral blood vessel
  • Full-range complex-conjugate-free optical coherence tomography
  • graphics processing unit
  • neurosurgery

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Zhang, K., Huang, Y., Pradilla, G., Tyler, B. M., & Kang, J. U. (2011). Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7883). [78833Y] https://doi.org/10.1117/12.874190

Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery. / Zhang, Kang; Huang, Yong; Pradilla, Gustavo; Tyler, Betty Mae; Kang, Jin U.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011. 78833Y.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zhang, K, Huang, Y, Pradilla, G, Tyler, BM & Kang, JU 2011, Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 7883, 78833Y, Photonic Therapeutics and Diagnostics VII, San Francisco, CA, United States, 1/22/11. https://doi.org/10.1117/12.874190
Zhang K, Huang Y, Pradilla G, Tyler BM, Kang JU. Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883. 2011. 78833Y https://doi.org/10.1117/12.874190
Zhang, Kang ; Huang, Yong ; Pradilla, Gustavo ; Tyler, Betty Mae ; Kang, Jin U. / Real-time intraoperative full-range complex FD-OCT guided cerebral blood vessel identification and brain tumor resection in neurosurgery. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 7883 2011.
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