Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography

Hongwu Ren, Tao Sun, Daniel J. MacDonald, Michael J. Cobb, Xingde Li

Research output: Contribution to journalArticle

Abstract

We present a moving-scatterer-sensitive optical Doppler tomography (MSS-ODT) technique for in vivo blood flow imaging in real time by using a spectral-domain optical coherence tomography system. In MSS-ODT the influence of stationary scatterers is suppressed by subtracting adjacent complex axial scans before calculating the Doppler frequency shift. We demonstrate that MSS-ODT is a useful technique for accurate determination of blood vessel size by imaging flow in a small capillary tube with a 75 μm inner diameter. The flow profile obtained with MSS-ODT yields a substantially more accurate tube diameter than that obtained with the conventional phase-resolved method, which underestimates the diameter by about 23%. We also demonstrate that MSS-ODT provides improved sensitivity over the conventional phase-resolved method for imaging in vivo blood flow in small vessels in a mouse ear.

Original languageEnglish (US)
Pages (from-to)927-929
Number of pages3
JournalOptics Letters
Volume31
Issue number7
DOIs
StatePublished - Apr 1 2006
Externally publishedYes

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blood flow
tomography
scattering
capillary tubes
blood vessels
ear
frequency shift
vessels
mice
tubes
sensitivity
profiles

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography. / Ren, Hongwu; Sun, Tao; MacDonald, Daniel J.; Cobb, Michael J.; Li, Xingde.

In: Optics Letters, Vol. 31, No. 7, 01.04.2006, p. 927-929.

Research output: Contribution to journalArticle

Ren, Hongwu ; Sun, Tao ; MacDonald, Daniel J. ; Cobb, Michael J. ; Li, Xingde. / Real-time in vivo blood-flow imaging by moving-scatterer-sensitive spectral-domain optical Doppler tomography. In: Optics Letters. 2006 ; Vol. 31, No. 7. pp. 927-929.
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