Real-time imaging of two-dimensional cardiac strain using a harmonic phase magnetic resonance imaging (HARP-MRI) pulse sequence

Smita Sampath, J. Andrew Derbyshire, Ergin Atalar, Nael F. Osman, Jerry L. Prince

Research output: Contribution to journalArticlepeer-review

Abstract

The harmonic phase (HARP) method provides automatic and rapid analysis of tagged magnetic resonance (MR) images for quantification and visualization of myocardial strain. In this article, the development and implementation of a pulse sequence that acquires HARP images in real time are described. In this pulse sequence, a CINE sequence of images with 1-1 spatial modulation of magnetization (SPAMM) tags are acquired during each cardiac cycle, alternating between vertical and horizontal tags in successive heartbeats. An incrementing train of imaging RF flip angles is used to compensate for the decay of the harmonic peaks due to both T1 relaxation and the applied imaging pulses. The magnitude images displaying coarse anatomy are automatically reconstructed and displayed in real time after each heartbeat. HARP strain images are generated offline at a rate of four images per second; real-time processing should be possible with faster algorithms or computers. A comparison of myocardial contractility in non-breath-hold and breath-hold experiments in normal humans is presented.

Original languageEnglish (US)
Pages (from-to)154-163
Number of pages10
JournalMagnetic resonance in medicine
Volume50
Issue number1
DOIs
StatePublished - Jul 1 2003

Keywords

  • Cardiac motion
  • FastHARP
  • Harmonic phase
  • Magnetic resonance tagging
  • Myocardial strain
  • Real-time imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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