Reaginic antibody formation in the mouse. VIII. Depression of the ongoing IgE antibody formation by suppressor T cells

K. Takatsu, K. Ishizaka

Research output: Contribution to journalArticle

Abstract

The ongoing IgE antibody formation against ovalbumin (OA) in high responder mice was depressed by i.v. injections of either native or urea denatured ovalbumin (UD OA). Adoptive transfer experiments to determine the helper function of spleen cells from the treated animals showed that helper function for both IgE and IgG antibody responses diminished after treatment. Evidence was obtained that treatment suppressed the expansion of IgE B memory cells. When the same treatment with OA or UD OA was given to OA primed mice before the appearance of IgE antibody in their serum, OA specific splenic suppressor T cells were demonstrable. Thus, the transfer of splenic T cells from treated mice into normal mice suppressed the primary IgE and IgG antibody responses of the recipients to DNP OA. It was also found that the transfer of the splenic T cells from UD OA treated mice into OA primed mice depressed ongoing IgE antibody formation in the recipients. The results suggested strongly that the decrease of helper function and the depression of ongoing IgE antibody formation by repeated injections of UD OA was caused by generation of antigen (OA) specific suppressor T cells.

Original languageEnglish (US)
Pages (from-to)1211-1218
Number of pages8
JournalJournal of Immunology
Volume117
Issue number4
StatePublished - 1976

Fingerprint

Ovalbumin
Immunoglobulin E
Antibody Formation
T-Lymphocytes
Urea
Immunoglobulin G
Injections
Adoptive Transfer
Therapeutics
Spleen
Antigens
Antibodies
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Reaginic antibody formation in the mouse. VIII. Depression of the ongoing IgE antibody formation by suppressor T cells. / Takatsu, K.; Ishizaka, K.

In: Journal of Immunology, Vol. 117, No. 4, 1976, p. 1211-1218.

Research output: Contribution to journalArticle

@article{2d5db293e1ff44f290b301538c46ce6f,
title = "Reaginic antibody formation in the mouse. VIII. Depression of the ongoing IgE antibody formation by suppressor T cells",
abstract = "The ongoing IgE antibody formation against ovalbumin (OA) in high responder mice was depressed by i.v. injections of either native or urea denatured ovalbumin (UD OA). Adoptive transfer experiments to determine the helper function of spleen cells from the treated animals showed that helper function for both IgE and IgG antibody responses diminished after treatment. Evidence was obtained that treatment suppressed the expansion of IgE B memory cells. When the same treatment with OA or UD OA was given to OA primed mice before the appearance of IgE antibody in their serum, OA specific splenic suppressor T cells were demonstrable. Thus, the transfer of splenic T cells from treated mice into normal mice suppressed the primary IgE and IgG antibody responses of the recipients to DNP OA. It was also found that the transfer of the splenic T cells from UD OA treated mice into OA primed mice depressed ongoing IgE antibody formation in the recipients. The results suggested strongly that the decrease of helper function and the depression of ongoing IgE antibody formation by repeated injections of UD OA was caused by generation of antigen (OA) specific suppressor T cells.",
author = "K. Takatsu and K. Ishizaka",
year = "1976",
language = "English (US)",
volume = "117",
pages = "1211--1218",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "4",

}

TY - JOUR

T1 - Reaginic antibody formation in the mouse. VIII. Depression of the ongoing IgE antibody formation by suppressor T cells

AU - Takatsu, K.

AU - Ishizaka, K.

PY - 1976

Y1 - 1976

N2 - The ongoing IgE antibody formation against ovalbumin (OA) in high responder mice was depressed by i.v. injections of either native or urea denatured ovalbumin (UD OA). Adoptive transfer experiments to determine the helper function of spleen cells from the treated animals showed that helper function for both IgE and IgG antibody responses diminished after treatment. Evidence was obtained that treatment suppressed the expansion of IgE B memory cells. When the same treatment with OA or UD OA was given to OA primed mice before the appearance of IgE antibody in their serum, OA specific splenic suppressor T cells were demonstrable. Thus, the transfer of splenic T cells from treated mice into normal mice suppressed the primary IgE and IgG antibody responses of the recipients to DNP OA. It was also found that the transfer of the splenic T cells from UD OA treated mice into OA primed mice depressed ongoing IgE antibody formation in the recipients. The results suggested strongly that the decrease of helper function and the depression of ongoing IgE antibody formation by repeated injections of UD OA was caused by generation of antigen (OA) specific suppressor T cells.

AB - The ongoing IgE antibody formation against ovalbumin (OA) in high responder mice was depressed by i.v. injections of either native or urea denatured ovalbumin (UD OA). Adoptive transfer experiments to determine the helper function of spleen cells from the treated animals showed that helper function for both IgE and IgG antibody responses diminished after treatment. Evidence was obtained that treatment suppressed the expansion of IgE B memory cells. When the same treatment with OA or UD OA was given to OA primed mice before the appearance of IgE antibody in their serum, OA specific splenic suppressor T cells were demonstrable. Thus, the transfer of splenic T cells from treated mice into normal mice suppressed the primary IgE and IgG antibody responses of the recipients to DNP OA. It was also found that the transfer of the splenic T cells from UD OA treated mice into OA primed mice depressed ongoing IgE antibody formation in the recipients. The results suggested strongly that the decrease of helper function and the depression of ongoing IgE antibody formation by repeated injections of UD OA was caused by generation of antigen (OA) specific suppressor T cells.

UR - http://www.scopus.com/inward/record.url?scp=0017109549&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017109549&partnerID=8YFLogxK

M3 - Article

C2 - 61994

AN - SCOPUS:0017109549

VL - 117

SP - 1211

EP - 1218

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 4

ER -