Reaginic antibody formation in the mouse. VII. Induction of suppressor T cells for IgE and IgG antibody responses

K. Takatsu, K. Ishizaka

Research output: Contribution to journalArticle

Abstract

Intravenous injections of urea denatured ovalbumin (UD OA) into OA primed high responder mice suppressed the antibody response not only to the priming antigen but also to subsequent immunization with dinitrophenyl derivatives of OA (DNP OA). The transfer of normal spleen cells or OA primed spleen cells into UD OA treated animals did not restore the capacity of responding to DNP OA to form anti DNP IgE and IgG antibodies. The transfer of splenic T cell fraction from the UD OA treated animals into normal syngeneic mice diminished both IgE and IgG antibody responses of the recipients to DNP OA. The B cell rich fraction from the same donors failed to affect the antihapten antibody response and enhanced anti carrier (OA) IgG antibody response of the recipients. It was also found that the transfer of the T cell rich fraction of OA primed spleen cells failed to suppress antibody response of the recipients to DNP OA. The results indicated that spleen cells of UD OA treated mice contained suppressor T cells which are distinct from helper cells. Suppressive activity of T cells in the UD OA treated animals was specific for OA. The transfer of the T cell rich fraction failed to suppress anti DNP antibody response of the recipients to DNP KLH.

Original languageEnglish (US)
Pages (from-to)1257-1264
Number of pages8
JournalJournal of Immunology
Volume116
Issue number5
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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