Reader performance in the ultrasonographic evaluation of oropharyngeal carcinoma

Farhoud Faraji, Ericka S. Padilla, Dana Blitz, Meghan B. Wenderoth, Ray G. Blanco, Satomi Kawamoto, Sheila Sheth, Ulrike M. Hamper, Carole Fakhry

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To examine reader performance in evaluating oropharyngeal anatomy on ultrasonography. Materials and methods Ultrasound images of the oropharynx comprising normal and malignant anatomic variants were organized into slideshows. Slideshows were administered to 6 readers blinded to participant tumor status and with varying experience reading oropharyngeal sonograms. A training slideshow oriented readers to images of the oropharynx with and without malignant lesions. Readers then evaluated images in a test slideshow for tumor presence and marked orthogonal long and short dimensions of the tumor. Results were analyzed for accuracy, sensitivity, specificity, inter-reader agreement, and measurement error relative to prospectively-identified reference measurements. Results Eighty-seven percent of base of tongue (BOT) sonograms were identified correctly by a majority of readers. In identifying BOT tumors, median accuracy, sensitivity, specificity, and Fleiss's kappa were 79%, 73%, 85%, and 0.51, respectively. Median measurement error in the long and short axes for BOT tumors was −2.6% (range: −40% to 29%) and −2.6% (range: −56% to 156%), respectively. Eighty-four percent of palatine tonsil sonograms were identified correctly by a majority of readers. In identifying tonsil tumors, median accuracy, sensitivity, specificity, and Fleiss's kappa were 77%, 74%, 78%, and 0.41, respectively. Median measurement error in the long and short axes for tonsil tumors was 3.8% (range: −45% to 32%) and −6.5% (range: −83% to 42%), respectively. Conclusions Overall, US has clinically useful sensitivity for identification of oropharyngeal carcinoma among readers of diverse clinical backgrounds and experience. US may be useful for the evaluation of features such as tumor dimensions.

Original languageEnglish (US)
Pages (from-to)105-110
Number of pages6
JournalOral Oncology
Volume77
DOIs
StatePublished - Feb 2018

Keywords

  • Base of tongue
  • HNSCC
  • Head and neck
  • OPSCC
  • Oropharyngeal
  • Squamous cell carcinoma
  • Tonsil
  • Ultrasound

ASJC Scopus subject areas

  • Oral Surgery
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Reader performance in the ultrasonographic evaluation of oropharyngeal carcinoma'. Together they form a unique fingerprint.

Cite this