Reactive oxygen species as mediators of cellular senescence

Renata Colavitti, Toren Finkel

Research output: Contribution to journalArticle

Abstract

Aging has often been viewed as a random process arising from the accumulation of both genetic and epigenetic changes. Increasingly, the notion that aging is a stochastic process is being supplanted by the concept that maximum lifespan of an organism is tightly regulated. This knowledge has led to a growing overlap between classical signal transduction paradigms and the biology of aging. We review certain specific examples where these seemingly disparate disciplines intersect. In particular, we review the concept that intracellular reactive oxygen species function as signalling molecules and that oxidants play a central role as mediators of cellular senescence.

Original languageEnglish (US)
Pages (from-to)277-281
Number of pages5
JournalIUBMB Life
Volume57
Issue number4-5
DOIs
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Cell senescence
  • Reactive oxygen species
  • Telomerase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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