Abstract
Aging has often been viewed as a random process arising from the accumulation of both genetic and epigenetic changes. Increasingly, the notion that aging is a stochastic process is being supplanted by the concept that maximum lifespan of an organism is tightly regulated. This knowledge has led to a growing overlap between classical signal transduction paradigms and the biology of aging. We review certain specific examples where these seemingly disparate disciplines intersect. In particular, we review the concept that intracellular reactive oxygen species function as signalling molecules and that oxidants play a central role as mediators of cellular senescence.
Original language | English (US) |
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Pages (from-to) | 277-281 |
Number of pages | 5 |
Journal | IUBMB Life |
Volume | 57 |
Issue number | 4-5 |
DOIs | |
State | Published - Apr 2005 |
Externally published | Yes |
Keywords
- Cell senescence
- Reactive oxygen species
- Telomerase
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology