Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus

Smriti Mehra, Nadia A. Golden, Noton Dutta, Cecily C. Midkiff, X. Alvarez, Lara A. Doyle, Majdouline Asher, Kasi Russell-Lodrigue, Chris Monjure, Chad J. Roy, James L. Blanchard, Peter J. Didier, Ronald S. Veazey, Andrew A. Lackner, Deepak Kaushal

Research output: Contribution to journalArticle

Abstract

Background: Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3million deaths every year are attributed to these twin epidemics. Annually, ~11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV). Results A low-dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus-specific strain of SIV significantly reactivated TB. Conclusions Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.

Original languageEnglish (US)
Pages (from-to)233-243
Number of pages11
JournalJournal of Medical Primatology
Volume40
Issue number4
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

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Keywords

  • Latency
  • M. tuberculosis
  • Macaque
  • Non-human primate
  • Reactivation
  • TB/AIDS coinfection

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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