Reaction of nitric oxide with hemoglobin

Clara Fronticelli, M. Karavitis

Research output: Contribution to journalArticle

Abstract

The reaction of hemoglobin with nitric oxide has been investigated by recording absorbtion spectra of human hemoglobin in time, in the presence of different ligands. The results are summarized in the figure. They suggest that the combination of the various derivatives of hemoglobin with NO would converge to the formation of methemoglobin [Hb(III)], establishing a redox cycle which depletes the nitric oxide being produced.

Original languageEnglish (US)
JournalArtificial Cells, Blood Substitutes, and Biotechnology
Volume22
Issue number5
StatePublished - Nov 1994
Externally publishedYes

Fingerprint

Hemoglobin
Nitric oxide
Nitric Oxide
Hemoglobins
Methemoglobin
Oxidation-Reduction
Ligands
Derivatives
glycosylated-nitric oxide complex hemoglobin A

ASJC Scopus subject areas

  • Biotechnology
  • Biomedical Engineering
  • Biomaterials
  • Hematology

Cite this

Reaction of nitric oxide with hemoglobin. / Fronticelli, Clara; Karavitis, M.

In: Artificial Cells, Blood Substitutes, and Biotechnology, Vol. 22, No. 5, 11.1994.

Research output: Contribution to journalArticle

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