Understanding the mechanisms which contribute to successful growth and function of the pancreatic b-cell is essential to our ability to combat the global epidemic of diabetes. To date, there is limited in vivo data addressing the role of microRNAs or components of the RNAi machinery in the pancreatic β-cell. In this issue of The EMBO Journal, Melkman-Zehavi et al provide further evidence of howsmall RNAs contribute to the normal growth and function of this cell type, characterizing the metabolic consequences of Dicer depletion. Their study highlights the role of miR-24, miR-26, and miR-148 in promoting insulin mRNA levels and begins to suggest potential for many other microRNAs to contribute to an already complex story.
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)