Re-dicing the pancreatic β 2-cell: Do microRNAs define cellular identity?

Sudhir Gopal Tattikota; Matthew N. Poy

doi:10.1038/emboj.2011.31

Re-dicing the pancreatic β 2-cell: Do microRNAs define cellular identity?

Sudhir Gopal Tattikota, Matthew N. Poy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Understanding the mechanisms which contribute to successful growth and function of the pancreatic b-cell is essential to our ability to combat the global epidemic of diabetes. To date, there is limited in vivo data addressing the role of microRNAs or components of the RNAi machinery in the pancreatic β-cell. In this issue of The EMBO Journal, Melkman-Zehavi et al provide further evidence of howsmall RNAs contribute to the normal growth and function of this cell type, characterizing the metabolic consequences of Dicer depletion. Their study highlights the role of miR-24, miR-26, and miR-148 in promoting insulin mRNA levels and begins to suggest potential for many other microRNAs to contribute to an already complex story.

Original language	English (US)
Pages (from-to)	797-799
Number of pages	3
Journal	EMBO Journal
Volume	30
Issue number	5
DOIs	https://doi.org/10.1038/emboj.2011.31
State	Published - Mar 2 2011
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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10.1038/emboj.2011.31

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Re-dicing the pancreatic β 2-cell: Do microRNAs define cellular identity?

Abstract

ASJC Scopus subject areas

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