Abstract
Raynaud's phenomenon is a common clinical problem occurring in 3% to 5% of the general population. The first symptom of scleroderma is often Raynaud's phenomenon, which is associated with a diffuse small vessel vasculopathy, and ischemia and reperfusion injury to skin and other organs targeted in this disease. Current studies support the concept that Raynaud's phenomenon is secondary to a local defect in the regulation of regional blood flow. New evidence demonstrates that there is a profound sensitivity to α2-adrenoceptors mediated vasoconstriction in scleroderma vessels. Traditional treatment of Raynaud's phenomenon is cold avoidance and the use of vasodilators. Oral prostaglandins have shown promise as therapeutic agents.
Original language | English (US) |
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Pages (from-to) | 765-781 |
Number of pages | 17 |
Journal | Rheumatic Disease Clinics of North America |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - 1996 |
ASJC Scopus subject areas
- Rheumatology