Rationale for use of local hyperthermia with radiation therapy and selected anticancer drugs in locally advanced human malignancies

T. S. Herman, B. A. Teicher, M. Jochelson, J. Clark, G. Svensson, C. N. Coleman

Research output: Contribution to journalArticlepeer-review

Abstract

The addition of local hyperthermia to radiation therapy has significantly improved the ability of oncologists to control superficial malignancies. Large tumours, tumours which cannot be heated adequately, and those situated in areas where surrounding normal tissues have decreased radiation tolerance, however, are difficult to eradicate even with this combination treatment. We believe that properly selected and scheduled anticancer drugs will add substantially to the efficacy of local hyperthermia and radiation. A review of the literature concerning the cytotoxic interactions of various anticancer agents with hyperthermia, with radiation and with relevant physiological parameters is presented. From this review, anticancer drugs which are good candidates for trimodality therapy are identified and a general approach to trimodality scheduling is suggested.

Original languageEnglish (US)
Pages (from-to)143-158
Number of pages16
JournalInternational Journal of Hyperthermia
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1988

Keywords

  • Chemotherapy
  • Hyperthermia
  • Radiotherapy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cancer Research

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