Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method

Luis Ostrosky-Zeichner; John H. Rex; Michael A. Pfaller; Daniel J. Diekema; Barbara D. Alexander; David Andes; Steven D. Brown; Vishnu Chaturvedi; Mahmoud A. Ghannoum; Cindy C. Knapp; Daniel J. Sheehan; Thomas J. Walsh

doi:10.1128/AAC.00420-08

Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method

Luis Ostrosky-Zeichner, John H. Rex, Michael A. Pfaller, Daniel J. Diekema, Barbara D. Alexander, David Andes, Steven D. Brown, Vishnu Chaturvedi, Mahmoud A. Ghannoum, Cindy C. Knapp, Daniel J. Sheehan, Thomas J. Walsh

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

Original language	English (US)
Pages (from-to)	4175-4177
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	52
Issue number	11
DOIs	https://doi.org/10.1128/AAC.00420-08
State	Published - Nov 2008

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Ostrosky-Zeichner, L., Rex, J. H., Pfaller, M. A., Diekema, D. J., Alexander, B. D., Andes, D., Brown, S. D., Chaturvedi, V., Ghannoum, M. A., Knapp, C. C., Sheehan, D. J., & Walsh, T. J. (2008). Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method. Antimicrobial agents and chemotherapy, 52(11), 4175-4177. https://doi.org/10.1128/AAC.00420-08

Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method. / Ostrosky-Zeichner, Luis; Rex, John H.; Pfaller, Michael A.; Diekema, Daniel J.; Alexander, Barbara D.; Andes, David; Brown, Steven D.; Chaturvedi, Vishnu; Ghannoum, Mahmoud A.; Knapp, Cindy C.; Sheehan, Daniel J.; Walsh, Thomas J.

In: Antimicrobial agents and chemotherapy, Vol. 52, No. 11, 11.2008, p. 4175-4177.

Research output: Contribution to journal › Article › peer-review

Ostrosky-Zeichner, L, Rex, JH, Pfaller, MA, Diekema, DJ, Alexander, BD, Andes, D, Brown, SD, Chaturvedi, V, Ghannoum, MA, Knapp, CC, Sheehan, DJ & Walsh, TJ 2008, 'Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method', Antimicrobial agents and chemotherapy, vol. 52, no. 11, pp. 4175-4177. https://doi.org/10.1128/AAC.00420-08

Ostrosky-Zeichner, Luis ; Rex, John H. ; Pfaller, Michael A. ; Diekema, Daniel J. ; Alexander, Barbara D. ; Andes, David ; Brown, Steven D. ; Chaturvedi, Vishnu ; Ghannoum, Mahmoud A. ; Knapp, Cindy C. ; Sheehan, Daniel J. ; Walsh, Thomas J. / Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method. In: Antimicrobial agents and chemotherapy. 2008 ; Vol. 52, No. 11. pp. 4175-4177.

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abstract = "We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.",

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