Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method

Luis Ostrosky-Zeichner, John H. Rex, Michael A. Pfaller, Daniel J. Diekema, Barbara D. Alexander, David Andes, Steven D. Brown, Vishnu Chaturvedi, Mahmoud A. Ghannoum, Cindy C. Knapp, Daniel J. Sheehan, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

Original languageEnglish (US)
Pages (from-to)4175-4177
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume52
Issue number11
DOIs
StatePublished - Nov 2008

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method'. Together they form a unique fingerprint.

Cite this