Rationale and design of the national emphysema treatment trial: A prospective randomized trial of lung volume reduction surgery

Steven Piantadosi

    Research output: Contribution to journalArticle

    Abstract

    The National Emphysema Treatment Trial is a multicenter, randomized clinical trial of medical therapy vs medical therapy plus lung volume reduction surgery (LVRS) for the treatment of patients with severe bilateral emphysema. LVRS will be accomplished by bilateral stapled excision via median sternotomy or video-assisted thoracoscopic surgery. Every patient will complete 6 to 10 weeks of pulmonary rehabilitation prior to randomization and will participate in a maintenance program of pulmonary rehabilitation after randomization. The primary outcome to be assessed by the trial is survival. Additional outcomes to be assessed are maximum exercise capacity, pulmonary function, oxygen requirement, distance walked in 6 min, quality of life, respiratory symptoms, and health-care utilization and costs. In addition, selected clinics will evaluate lung mechanics and respiratory muscle function, partial and maximal flow-volume curves, gas exchange during maximal exercise, and right heart function. The trial is targeted to enroll patients with severe emphysema who have no significant comorbid conditions; each patient will be randomized to one of the two treatment groups. The study duration is 4.5 years with a close-out period of 6 months.

    Original languageEnglish (US)
    Pages (from-to)1750-1761
    Number of pages12
    JournalChest
    Volume116
    Issue number6
    StatePublished - 1999

    Fingerprint

    Pneumonectomy
    Emphysema
    Lung
    Random Allocation
    Rehabilitation
    Patient Acceptance of Health Care
    Exercise
    Therapeutics
    Video-Assisted Thoracic Surgery
    Respiratory Muscles
    Sternotomy
    Mechanics
    Health Care Costs
    Randomized Controlled Trials
    Gases
    Maintenance
    Quality of Life
    Oxygen
    Survival

    Keywords

    • Emphysema
    • Lung function
    • Lung volume reduction surgery
    • Maximum exercise capacity
    • Median sternotomy
    • Medical vs surgical treatment
    • Pulmonary rehabilitation
    • Randomized clinical trial
    • Video-assisted thoracoscopic surgery

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine

    Cite this

    Rationale and design of the national emphysema treatment trial : A prospective randomized trial of lung volume reduction surgery. / Piantadosi, Steven.

    In: Chest, Vol. 116, No. 6, 1999, p. 1750-1761.

    Research output: Contribution to journalArticle

    @article{c39aa07164e84ed09d9a9cd75e438afb,
    title = "Rationale and design of the national emphysema treatment trial: A prospective randomized trial of lung volume reduction surgery",
    abstract = "The National Emphysema Treatment Trial is a multicenter, randomized clinical trial of medical therapy vs medical therapy plus lung volume reduction surgery (LVRS) for the treatment of patients with severe bilateral emphysema. LVRS will be accomplished by bilateral stapled excision via median sternotomy or video-assisted thoracoscopic surgery. Every patient will complete 6 to 10 weeks of pulmonary rehabilitation prior to randomization and will participate in a maintenance program of pulmonary rehabilitation after randomization. The primary outcome to be assessed by the trial is survival. Additional outcomes to be assessed are maximum exercise capacity, pulmonary function, oxygen requirement, distance walked in 6 min, quality of life, respiratory symptoms, and health-care utilization and costs. In addition, selected clinics will evaluate lung mechanics and respiratory muscle function, partial and maximal flow-volume curves, gas exchange during maximal exercise, and right heart function. The trial is targeted to enroll patients with severe emphysema who have no significant comorbid conditions; each patient will be randomized to one of the two treatment groups. The study duration is 4.5 years with a close-out period of 6 months.",
    keywords = "Emphysema, Lung function, Lung volume reduction surgery, Maximum exercise capacity, Median sternotomy, Medical vs surgical treatment, Pulmonary rehabilitation, Randomized clinical trial, Video-assisted thoracoscopic surgery",
    author = "Steven Piantadosi",
    year = "1999",
    language = "English (US)",
    volume = "116",
    pages = "1750--1761",
    journal = "Chest",
    issn = "0012-3692",
    publisher = "American College of Chest Physicians",
    number = "6",

    }

    TY - JOUR

    T1 - Rationale and design of the national emphysema treatment trial

    T2 - A prospective randomized trial of lung volume reduction surgery

    AU - Piantadosi, Steven

    PY - 1999

    Y1 - 1999

    N2 - The National Emphysema Treatment Trial is a multicenter, randomized clinical trial of medical therapy vs medical therapy plus lung volume reduction surgery (LVRS) for the treatment of patients with severe bilateral emphysema. LVRS will be accomplished by bilateral stapled excision via median sternotomy or video-assisted thoracoscopic surgery. Every patient will complete 6 to 10 weeks of pulmonary rehabilitation prior to randomization and will participate in a maintenance program of pulmonary rehabilitation after randomization. The primary outcome to be assessed by the trial is survival. Additional outcomes to be assessed are maximum exercise capacity, pulmonary function, oxygen requirement, distance walked in 6 min, quality of life, respiratory symptoms, and health-care utilization and costs. In addition, selected clinics will evaluate lung mechanics and respiratory muscle function, partial and maximal flow-volume curves, gas exchange during maximal exercise, and right heart function. The trial is targeted to enroll patients with severe emphysema who have no significant comorbid conditions; each patient will be randomized to one of the two treatment groups. The study duration is 4.5 years with a close-out period of 6 months.

    AB - The National Emphysema Treatment Trial is a multicenter, randomized clinical trial of medical therapy vs medical therapy plus lung volume reduction surgery (LVRS) for the treatment of patients with severe bilateral emphysema. LVRS will be accomplished by bilateral stapled excision via median sternotomy or video-assisted thoracoscopic surgery. Every patient will complete 6 to 10 weeks of pulmonary rehabilitation prior to randomization and will participate in a maintenance program of pulmonary rehabilitation after randomization. The primary outcome to be assessed by the trial is survival. Additional outcomes to be assessed are maximum exercise capacity, pulmonary function, oxygen requirement, distance walked in 6 min, quality of life, respiratory symptoms, and health-care utilization and costs. In addition, selected clinics will evaluate lung mechanics and respiratory muscle function, partial and maximal flow-volume curves, gas exchange during maximal exercise, and right heart function. The trial is targeted to enroll patients with severe emphysema who have no significant comorbid conditions; each patient will be randomized to one of the two treatment groups. The study duration is 4.5 years with a close-out period of 6 months.

    KW - Emphysema

    KW - Lung function

    KW - Lung volume reduction surgery

    KW - Maximum exercise capacity

    KW - Median sternotomy

    KW - Medical vs surgical treatment

    KW - Pulmonary rehabilitation

    KW - Randomized clinical trial

    KW - Video-assisted thoracoscopic surgery

    UR - http://www.scopus.com/inward/record.url?scp=0033380191&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0033380191&partnerID=8YFLogxK

    M3 - Article

    C2 - 10593802

    AN - SCOPUS:0033380191

    VL - 116

    SP - 1750

    EP - 1761

    JO - Chest

    JF - Chest

    SN - 0012-3692

    IS - 6

    ER -