Rational combinations of immunotherapy for pancreatic ductal adenocarcinoma

Alex B. Blair, Lei Zheng

Research output: Contribution to journalReview article

Abstract

The complex interaction between the immune system, the tumor and the microenvironment in pancreatic ductal adenocarcinoma (PDA) leads to the resistance of PDA to immunotherapy. To overcome this resistance, combination immunotherapy is being proposed. However, rational combinations that target multiple aspects of the complex anti-tumor immune response are warranted. Novel clinical trials will investigate and optimize the combination immunotherapy for PDA.

Original languageEnglish (US)
Article number31
JournalChinese Clinical Oncology
Volume6
Issue number3
DOIs
StatePublished - Jun 1 2017

Keywords

  • Checkpoint inhibitors
  • Combination immunotherapy
  • GVAX
  • Immunotherapy
  • Pancreatic cancer
  • Vaccine therapy

ASJC Scopus subject areas

  • Oncology

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