Rates of tetanus protection and transplacental tetanus antibody transfer in pregnant women from different socioeconomic groups in Peru

Guillermo Madico, Guillermo Salazar, Jeff McDonald, William Checkley, Maritza Calderón, Manuela Verastegui, Robert H. Gilman

Research output: Contribution to journalArticle

Abstract

In developing countries, neonatal tetanus causes significant mortality. Using a new competitive enzyme-linked immunosorbent assay to measure anti-tetanus toxin antibody levels, we compared rates of protection, total antibody levels, and maternal-to-fetal antibody ratios between different socioeconomic groups in Peru. Upper-middle-class women 25 years and older had significantly lower rates of protection and mean antitetanus toxin antibody levels than did lower-class women of the same age. Nevertheless, the former had higher fetal-to-maternal antibody ratios, independent of maternal age, total antibody levels, or parity. We conclude that future vaccination programs in Latin America must target upper-middle-class as well as lower-class women.

Original languageEnglish (US)
Pages (from-to)753-755
Number of pages3
JournalClinical and Diagnostic Laboratory Immunology
Volume3
Issue number6
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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