Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects

A. E. Brown, J. R. Lane, K. F. Wagner, S. Zhou, R. Chung, K. L. Ray, S. P. Blatt, D. S. Burke

Research output: Contribution to journalArticle

Abstract

Objective: To determine the relative frequencies of HIV-1 p24 antigen and culture positivity in white and black patients. Design: Volunteers in the US military's HIV natural history study were 46% white, 44% black, 7% Hispanic and 3% other. Focusing on the comparable groups of whites and blacks, a retrospective analysis was performed of the results of virologic assays collected over a 2-year period. Methods: p24 antigen was quantitated in sera with and without immune complex dissociation (ICD); viral isolation was performed by coculture of peripheral blood mononuclear cells. Results: Results of the two virologic assays were very similar in the two racial groups, both overall and after stratification by CD4 cell count. As reported previously, the concentration of serum immunoglobulin G was found to be greater in black than white subjects. In contrast to results with ICD, sera tested without ICD resulted in differing (higher) rates of antigenemia in whites than blacks (P = 0.002). Conclusions: The frequencies of p24 antigen and culture positivity were found to be independent of race. Previously observed racial differences in antigen positivity were likely to be due to more extensive antibody binding in blacks than in whites.

Original languageEnglish (US)
Pages (from-to)325-328
Number of pages4
JournalAIDS
Volume9
Issue number4
StatePublished - 1995
Externally publishedYes

Fingerprint

HIV
Antigen-Antibody Complex
Antigens
Serum
HIV Core Protein p24
CD4 Lymphocyte Count
Coculture Techniques
Natural History
Hispanic Americans
hydroquinone
HIV-1
Volunteers
Blood Cells
Immunoglobulin G
Antibodies

Keywords

  • AIDS
  • HIV
  • Military medicine
  • p24 antigen
  • Race

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Brown, A. E., Lane, J. R., Wagner, K. F., Zhou, S., Chung, R., Ray, K. L., ... Burke, D. S. (1995). Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects. AIDS, 9(4), 325-328.

Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects. / Brown, A. E.; Lane, J. R.; Wagner, K. F.; Zhou, S.; Chung, R.; Ray, K. L.; Blatt, S. P.; Burke, D. S.

In: AIDS, Vol. 9, No. 4, 1995, p. 325-328.

Research output: Contribution to journalArticle

Brown, AE, Lane, JR, Wagner, KF, Zhou, S, Chung, R, Ray, KL, Blatt, SP & Burke, DS 1995, 'Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects', AIDS, vol. 9, no. 4, pp. 325-328.
Brown AE, Lane JR, Wagner KF, Zhou S, Chung R, Ray KL et al. Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects. AIDS. 1995;9(4):325-328.
Brown, A. E. ; Lane, J. R. ; Wagner, K. F. ; Zhou, S. ; Chung, R. ; Ray, K. L. ; Blatt, S. P. ; Burke, D. S. / Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects. In: AIDS. 1995 ; Vol. 9, No. 4. pp. 325-328.
@article{452183577c1f44a9ae219a031c0eed05,
title = "Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects",
abstract = "Objective: To determine the relative frequencies of HIV-1 p24 antigen and culture positivity in white and black patients. Design: Volunteers in the US military's HIV natural history study were 46{\%} white, 44{\%} black, 7{\%} Hispanic and 3{\%} other. Focusing on the comparable groups of whites and blacks, a retrospective analysis was performed of the results of virologic assays collected over a 2-year period. Methods: p24 antigen was quantitated in sera with and without immune complex dissociation (ICD); viral isolation was performed by coculture of peripheral blood mononuclear cells. Results: Results of the two virologic assays were very similar in the two racial groups, both overall and after stratification by CD4 cell count. As reported previously, the concentration of serum immunoglobulin G was found to be greater in black than white subjects. In contrast to results with ICD, sera tested without ICD resulted in differing (higher) rates of antigenemia in whites than blacks (P = 0.002). Conclusions: The frequencies of p24 antigen and culture positivity were found to be independent of race. Previously observed racial differences in antigen positivity were likely to be due to more extensive antibody binding in blacks than in whites.",
keywords = "AIDS, HIV, Military medicine, p24 antigen, Race",
author = "Brown, {A. E.} and Lane, {J. R.} and Wagner, {K. F.} and S. Zhou and R. Chung and Ray, {K. L.} and Blatt, {S. P.} and Burke, {D. S.}",
year = "1995",
language = "English (US)",
volume = "9",
pages = "325--328",
journal = "AIDS",
issn = "0269-9370",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects

AU - Brown, A. E.

AU - Lane, J. R.

AU - Wagner, K. F.

AU - Zhou, S.

AU - Chung, R.

AU - Ray, K. L.

AU - Blatt, S. P.

AU - Burke, D. S.

PY - 1995

Y1 - 1995

N2 - Objective: To determine the relative frequencies of HIV-1 p24 antigen and culture positivity in white and black patients. Design: Volunteers in the US military's HIV natural history study were 46% white, 44% black, 7% Hispanic and 3% other. Focusing on the comparable groups of whites and blacks, a retrospective analysis was performed of the results of virologic assays collected over a 2-year period. Methods: p24 antigen was quantitated in sera with and without immune complex dissociation (ICD); viral isolation was performed by coculture of peripheral blood mononuclear cells. Results: Results of the two virologic assays were very similar in the two racial groups, both overall and after stratification by CD4 cell count. As reported previously, the concentration of serum immunoglobulin G was found to be greater in black than white subjects. In contrast to results with ICD, sera tested without ICD resulted in differing (higher) rates of antigenemia in whites than blacks (P = 0.002). Conclusions: The frequencies of p24 antigen and culture positivity were found to be independent of race. Previously observed racial differences in antigen positivity were likely to be due to more extensive antibody binding in blacks than in whites.

AB - Objective: To determine the relative frequencies of HIV-1 p24 antigen and culture positivity in white and black patients. Design: Volunteers in the US military's HIV natural history study were 46% white, 44% black, 7% Hispanic and 3% other. Focusing on the comparable groups of whites and blacks, a retrospective analysis was performed of the results of virologic assays collected over a 2-year period. Methods: p24 antigen was quantitated in sera with and without immune complex dissociation (ICD); viral isolation was performed by coculture of peripheral blood mononuclear cells. Results: Results of the two virologic assays were very similar in the two racial groups, both overall and after stratification by CD4 cell count. As reported previously, the concentration of serum immunoglobulin G was found to be greater in black than white subjects. In contrast to results with ICD, sera tested without ICD resulted in differing (higher) rates of antigenemia in whites than blacks (P = 0.002). Conclusions: The frequencies of p24 antigen and culture positivity were found to be independent of race. Previously observed racial differences in antigen positivity were likely to be due to more extensive antibody binding in blacks than in whites.

KW - AIDS

KW - HIV

KW - Military medicine

KW - p24 antigen

KW - Race

UR - http://www.scopus.com/inward/record.url?scp=0028923226&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028923226&partnerID=8YFLogxK

M3 - Article

C2 - 7794537

AN - SCOPUS:0028923226

VL - 9

SP - 325

EP - 328

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 4

ER -