Rat strain differences in flap tolerance to ischemia

E Gene Deune, R. K. Khouri

Research output: Contribution to journalArticle

Abstract

The rat epigastric island flap model is commonly used to explore ischemia- related phenomena. We sought to evaluate strain differeces in tolerance to ischemia using two commonly used rat strains: Sprague-Dawley and Lewis. Epigastric flaps (3 x 6 cm) based on the superficial epigastric artery and vein were raised bilaterally in each rat (2 flaps/rat). Ischemia was induced for 10, 12, 14, or 16 hours by placing temporary occlusion camps on each vessel of the vascular pedicle. Surviving flap areas were assessed planimetrically after 7 days. The average area of surviving flap tissue was greater in the Lewis rats for all iscemia times; this achieved significance for 12 hours and 14 hours of ischemia (P <0.005). These findings indicate that comparisons among studies on rat flap ischemia must take into account the particular strain used. Furthermore, these findings suggest an inherent capacity of Lewis rat tissue to withstand ischemia better than tissue of the Sprague-Dawley rat strain.

Original languageEnglish (US)
Pages (from-to)765-767
Number of pages3
JournalMicrosurgery
Volume16
Issue number11
DOIs
StatePublished - 1995
Externally publishedYes

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Ischemia
Sprague Dawley Rats
Epigastric Arteries
Surgical Flaps
Blood Vessels
Veins

ASJC Scopus subject areas

  • Surgery

Cite this

Rat strain differences in flap tolerance to ischemia. / Deune, E Gene; Khouri, R. K.

In: Microsurgery, Vol. 16, No. 11, 1995, p. 765-767.

Research output: Contribution to journalArticle

Deune, E Gene ; Khouri, R. K. / Rat strain differences in flap tolerance to ischemia. In: Microsurgery. 1995 ; Vol. 16, No. 11. pp. 765-767.
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