Rat jejunal absorptive function after intestinal transplantation - Effects of extrinsic denervation

Daniel H. Teitelbaum, Roberta E. Sonnino, David J. Dunaway, Gianna Stellin, Richard P. Harmel

Research output: Contribution to journalArticle

Abstract

Jejunal absorptive function was evaluated following small intestinal transplantation to determine the effects of extrinsic denervation. In particular, water and sodium absorption were measured following transplantation (denervated) and compared to a control group (Thiry-Vella). Water flow was initially secretory two days after transplantation (-41±27 μl/min/g dry tissue weight) but became absorptive at day 8 (25±25). Water flow in the Thiry-Vella group was not significantly different (P>0.05) from the transplant group at days 8 (17±7) and 10 (47±42). Sodium flows were also initially secretory in the transplant group and became absorptive. This study refutes previous claims that small bowel transplants have a deficiency of water absorption due to extrinsic denervation of the bowel and suggests normal absorptive function of water, electrolytes, and protein.

Original languageEnglish (US)
Pages (from-to)1099-1104
Number of pages6
JournalDigestive Diseases and Sciences
Volume38
Issue number6
DOIs
StatePublished - Jun 1 1993

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Keywords

  • albumin absorption
  • denervation
  • intestinal transplantation
  • sodium absorption
  • water absorption

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Teitelbaum, D. H., Sonnino, R. E., Dunaway, D. J., Stellin, G., & Harmel, R. P. (1993). Rat jejunal absorptive function after intestinal transplantation - Effects of extrinsic denervation. Digestive Diseases and Sciences, 38(6), 1099-1104. https://doi.org/10.1007/BF01295727