Rat brain endoplasmic reticulum calcium pools are anatomically and functionally segregated

Ajay Verma, Christopher A. Ross, Divya Verma, Surachai Supattapone, Solomon H. Snyder

Research output: Contribution to journalArticle

Abstract

Autoradiographic imaging can localize 45Ca2+ selectively accumulated via the Ca2+,Mg2+-ATPase into endoplasmic reticulum stores in rat brain slices. 45Ca2+ accumulation is markedly stimulated by oxalate and displays a heterogeneous distribution which resembles the mRNA distribution for a sarcoendoplasmic reticulum Ca2+,Mg2+-ATPase. Inositol 1,4,5-triphosphate1 [I(1,4,5)P3] inhibits 45Ca2+ accumulation selectively into regions corresponding to those enriched in I(1,4,5)P3 receptor-binding sites and in Ca2+,-Mg2+-ATPase mRNA. Thus rat brain endoplasmic reticulum calcium stores are anatomically and functionally differentiated.

Original languageEnglish (US)
Pages (from-to)781-790
Number of pages10
JournalMolecular biology of the cell
Volume1
Issue number10
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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