Abstract
Background. A 17-year-old white male with Crohn's disease who was receiving maintenance infusions of the anti-tumor necrosis factor (TNF) agent, infliximab, presented with a new-onset psoriasiform skin rash. The rash was not responsive to topical or oral corticosteroids and worsened after infliximab infusions and after subsequent administration of a second anti-TNF drug, adalimumab.Investigations. Full medical history and physical examination, including assessment of the morphology of rash and the temporal correlation with administration of anti-TNF agents.Diagnosis. Anti-TNF-agent induced psoriasiform skin rash.Management. Discontinuation of anti-TNF therapy. The patient opted to have his gastrointestinal symptoms treated with oral mesalazine and metronidazole.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 174-177 |
| Number of pages | 4 |
| Journal | Nature Reviews Gastroenterology and Hepatology |
| Volume | 7 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2010 |
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ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
Rash induced by anti-tumor necrosis factor agents in an adolescent with Crohn's disease. / Conklin, Laurie S.; Cohen, Bernard; Wilson, Lindsay; Cuffari, Carmelo; Oliva-Hemker, Maria.
In: Nature Reviews Gastroenterology and Hepatology, Vol. 7, No. 3, 03.2010, p. 174-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rash induced by anti-tumor necrosis factor agents in an adolescent with Crohn's disease
AU - Conklin, Laurie S.
AU - Cohen, Bernard
AU - Wilson, Lindsay
AU - Cuffari, Carmelo
AU - Oliva-Hemker, Maria
PY - 2010/3
Y1 - 2010/3
N2 - Background. A 17-year-old white male with Crohn's disease who was receiving maintenance infusions of the anti-tumor necrosis factor (TNF) agent, infliximab, presented with a new-onset psoriasiform skin rash. The rash was not responsive to topical or oral corticosteroids and worsened after infliximab infusions and after subsequent administration of a second anti-TNF drug, adalimumab.Investigations. Full medical history and physical examination, including assessment of the morphology of rash and the temporal correlation with administration of anti-TNF agents.Diagnosis. Anti-TNF-agent induced psoriasiform skin rash.Management. Discontinuation of anti-TNF therapy. The patient opted to have his gastrointestinal symptoms treated with oral mesalazine and metronidazole.
AB - Background. A 17-year-old white male with Crohn's disease who was receiving maintenance infusions of the anti-tumor necrosis factor (TNF) agent, infliximab, presented with a new-onset psoriasiform skin rash. The rash was not responsive to topical or oral corticosteroids and worsened after infliximab infusions and after subsequent administration of a second anti-TNF drug, adalimumab.Investigations. Full medical history and physical examination, including assessment of the morphology of rash and the temporal correlation with administration of anti-TNF agents.Diagnosis. Anti-TNF-agent induced psoriasiform skin rash.Management. Discontinuation of anti-TNF therapy. The patient opted to have his gastrointestinal symptoms treated with oral mesalazine and metronidazole.
UR - http://www.scopus.com/inward/record.url?scp=77749254887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77749254887&partnerID=8YFLogxK
U2 - 10.1038/nrgastro.2010.7
DO - 10.1038/nrgastro.2010.7
M3 - Article
C2 - 20203680
AN - SCOPUS:77749254887
VL - 7
SP - 174
EP - 177
JO - Nature Reviews Gastroenterology and Hepatology
JF - Nature Reviews Gastroenterology and Hepatology
SN - 1759-5045
IS - 3
ER -