RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study

Bert Vogelstein, Curt I. Civin, Antonette C. Preisinger, Jeffrey P. Krischer, Philip Steuber, Y. Ravindranath, Howard Weinstein, Peter Ellferich, Johannes Bos

Research output: Contribution to journalArticlepeer-review

Abstract

Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty‐four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalGenes, Chromosomes and Cancer
Volume2
Issue number2
DOIs
StatePublished - Jul 1990

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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