RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study

Bert Vogelstein, C. I. Civin, A. C. Preisinger, J. P. Krischer, P. Steuber, Y. Ravindranath, H. Weinstein, P. Elfferich, J. Bos

Research output: Contribution to journalArticle

Abstract

Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalGenes Chromosomes and Cancer
Volume2
Issue number2
StatePublished - 1990

Fingerprint

Acute Myeloid Leukemia
Pediatrics
Mutation
Genes
Codon
Oligonucleotides
Age Groups
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Vogelstein, B., Civin, C. I., Preisinger, A. C., Krischer, J. P., Steuber, P., Ravindranath, Y., ... Bos, J. (1990). RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study. Genes Chromosomes and Cancer, 2(2), 159-162.

RAS gene mutations in childhood acute myeloid leukemia : A pediatric oncology group study. / Vogelstein, Bert; Civin, C. I.; Preisinger, A. C.; Krischer, J. P.; Steuber, P.; Ravindranath, Y.; Weinstein, H.; Elfferich, P.; Bos, J.

In: Genes Chromosomes and Cancer, Vol. 2, No. 2, 1990, p. 159-162.

Research output: Contribution to journalArticle

Vogelstein, B, Civin, CI, Preisinger, AC, Krischer, JP, Steuber, P, Ravindranath, Y, Weinstein, H, Elfferich, P & Bos, J 1990, 'RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study', Genes Chromosomes and Cancer, vol. 2, no. 2, pp. 159-162.
Vogelstein B, Civin CI, Preisinger AC, Krischer JP, Steuber P, Ravindranath Y et al. RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study. Genes Chromosomes and Cancer. 1990;2(2):159-162.
Vogelstein, Bert ; Civin, C. I. ; Preisinger, A. C. ; Krischer, J. P. ; Steuber, P. ; Ravindranath, Y. ; Weinstein, H. ; Elfferich, P. ; Bos, J. / RAS gene mutations in childhood acute myeloid leukemia : A pediatric oncology group study. In: Genes Chromosomes and Cancer. 1990 ; Vol. 2, No. 2. pp. 159-162.
@article{5cc3a86f4f8445adb707ce83bb25e202,
title = "RAS gene mutations in childhood acute myeloid leukemia: A pediatric oncology group study",
abstract = "Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.",
author = "Bert Vogelstein and Civin, {C. I.} and Preisinger, {A. C.} and Krischer, {J. P.} and P. Steuber and Y. Ravindranath and H. Weinstein and P. Elfferich and J. Bos",
year = "1990",
language = "English (US)",
volume = "2",
pages = "159--162",
journal = "Genes Chromosomes and Cancer",
issn = "1045-2257",
publisher = "Wiley-Liss Inc.",
number = "2",

}

TY - JOUR

T1 - RAS gene mutations in childhood acute myeloid leukemia

T2 - A pediatric oncology group study

AU - Vogelstein, Bert

AU - Civin, C. I.

AU - Preisinger, A. C.

AU - Krischer, J. P.

AU - Steuber, P.

AU - Ravindranath, Y.

AU - Weinstein, H.

AU - Elfferich, P.

AU - Bos, J.

PY - 1990

Y1 - 1990

N2 - Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.

AB - Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.

UR - http://www.scopus.com/inward/record.url?scp=0024994577&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024994577&partnerID=8YFLogxK

M3 - Article

C2 - 2278970

AN - SCOPUS:0024994577

VL - 2

SP - 159

EP - 162

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

SN - 1045-2257

IS - 2

ER -