Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor

George Stathopoulos, A. Daniel Nourmand, Michael Blackstone, Dana Andersen, Alfred L. Baker

Research output: Contribution to journalArticle

Abstract

Two patients with sclerosing cholangitis presented with a distal stricture of the common bile duct in association with pancreatic pseudotumors. Jaundice resolved following surgery to correct biliary obstruction, but diffuse cholangio-graphic abnormalities and clinical evidence of sclerosing cholangitis became evident 2 and 4 months later. Rapid progression of symptomatic disease necessitated liver transplantation in one patient, but the other had a complete response to methotrexate therapy. The rapid disease progression in these two patients may have been triggered by surgery that resulted in a generalized fibroproliferative response of the biliary tree, already affected with localized sclerosing cholangitis contiguous to a pancreatic pseudotumor. We suggest that localized sclerosing cholangitis associated with pancreatic pseudo-tumors may be a unique variant that can progress rapidly but respond dramatically to antiinflammatory therapy.

Original languageEnglish (US)
Pages (from-to)143-148
Number of pages6
JournalJournal of Clinical Gastroenterology
Volume21
Issue number2
StatePublished - 1995
Externally publishedYes

Fingerprint

Sclerosing Cholangitis
Disease Progression
Common Bile Duct
Biliary Tract
Therapeutics
Jaundice
Methotrexate
Liver Transplantation
Pathologic Constriction
Anti-Inflammatory Agents
Neoplasms

Keywords

  • Pancreatic pseudotumors
  • Sclerosing cholangitis

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Stathopoulos, G., Daniel Nourmand, A., Blackstone, M., Andersen, D., & Baker, A. L. (1995). Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor. Journal of Clinical Gastroenterology, 21(2), 143-148.

Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor. / Stathopoulos, George; Daniel Nourmand, A.; Blackstone, Michael; Andersen, Dana; Baker, Alfred L.

In: Journal of Clinical Gastroenterology, Vol. 21, No. 2, 1995, p. 143-148.

Research output: Contribution to journalArticle

Stathopoulos, G, Daniel Nourmand, A, Blackstone, M, Andersen, D & Baker, AL 1995, 'Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor', Journal of Clinical Gastroenterology, vol. 21, no. 2, pp. 143-148.
Stathopoulos G, Daniel Nourmand A, Blackstone M, Andersen D, Baker AL. Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor. Journal of Clinical Gastroenterology. 1995;21(2):143-148.
Stathopoulos, George ; Daniel Nourmand, A. ; Blackstone, Michael ; Andersen, Dana ; Baker, Alfred L. / Rapidly progressive sclerosing cholangitis following surgical treatment of pancreatic pseudotumor. In: Journal of Clinical Gastroenterology. 1995 ; Vol. 21, No. 2. pp. 143-148.
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