Rapidly progressive organising pneumonia associated with cytomegalovirus infection in a patient with psoriasis

N. Messina, N. Scichilone, F. Guddo, V. Bellia

Research output: Contribution to journalArticlepeer-review

Abstract

A 63-year-old woman experienced progressive respiratory distress and psoriatic plaques. The radiographic images showed diffuse interstitial infiltrates. The surgical open lung biopsy revealed an obliteration of the alveolar spaces by plugs of connective tissue distributed within the terminal bronchioles, alveolar ducts and spaces. No relevant cause was determined, and she was diagnosed with idiopathic organising pneumonia. The patient was discharged with oral glucocorticosteroid and supplemental oxygen therapy. One month later, the patient's pulmonary status had progressively worsened, and she was re-admitted. She required higher oxygen concentrations and mechanical ventilation. Pharmacological therapy included high-dose steroids and cyclophosphamide. Serological assays revealed high antibodies titers (both IgM and IgG) to cytomegalovirus. Therefore, ganciclovir was added to the regimen. Despite the therapy, she died as a result of the disease. The review of the current literature on the topic is also presented.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalMonaldi Archives for Chest Disease - Pulmonary Series
Volume67
Issue number3
DOIs
StatePublished - Sep 2007

Keywords

  • Cytomegalovirus infection
  • Interstitial pneumonia
  • Psoriasis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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