Rapidly progressive metastatic cholangiocarcinoma in a postpartum patient with cystic fibrosis: a case report

Sara W. Carson, Kelly E. Craven, David Nauen, Kristina Montemayor, Mark Yarchoan, William R. Burns, Christian A. Merlo, Natalie E. West

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cholangiocarcinoma is a rare gastrointestinal malignancy that arises within the intrahepatic, perihilar, and/or extrahepatic bile ducts. Individuals with cystic fibrosis are at increased risk for gastrointestinal malignancies. The most common gastrointestinal malignancy in cystic fibrosis is colon cancer, but other gastrointestinal malignancies also occur at greater rates than the general population. Case presentation: We present a case of a rapidly progressive metastatic intrahepatic cholangiocarcinoma in an individual with cystic fibrosis who was 5 months postpartum, incidentally found while undergoing a lung transplantation evaluation. Conclusion: A heightened clinical awareness of gastrointestinal malignancies, beyond colon cancer, in individuals with cystic fibrosis is warranted. It remains unclear if pregnancy is an additional risk factor for gastrointestinal malignancies in cystic fibrosis.

Original languageEnglish (US)
Article number298
JournalBMC pulmonary medicine
Volume20
Issue number1
DOIs
StatePublished - Dec 2020

Keywords

  • Case report
  • Cholangiocarcinoma
  • Cystic fibrosis, pregnancy
  • Gastrointestinal cancer

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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