Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins

Monica Butcher, Daniela Puiu, Mark Romagnoli, Karen C Carroll, Steven L Salzberg, David W. Nauen

Research output: Contribution to journalArticlepeer-review

Abstract

Bloodstream infection with Bacillus cereus/thuringiensis can be life threatening, particularly in patients who are severely immunocompromised. In this report we describe a case that progressed from asymptomatic to fatal over approximately 5 hours despite extensive resuscitation efforts. We identify the pathogen and assemble its genome, in which we find genes for toxins that may have contributed to the precipitous demise. In the context of this and other cases we discuss the possible indication for rapid appropriate antibiotic administration and potentially antitoxin treatment or toxin removal in fulminant illness in immunocompromised patients.

Original languageEnglish (US)
Article number115534
JournalDiagnostic Microbiology and Infectious Disease
Volume101
Issue number4
DOIs
StatePublished - Dec 2021

Keywords

  • Bacillus cereus/thuringiensis
  • hematologic malignancy
  • immunocompromise
  • induction chemotherapy
  • sepsis

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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