Rapid steady‐state analysis of blood‐brain glucose transfer in rat

ALBERT GJEDDE

Research output: Contribution to journalArticlepeer-review

Abstract

A new kinetic analysis of blood‐brain glucose transport is described, based on a steady‐state model that takes account of cerebral blood flow, mean capillary glucose concentration, and cerebral metabolic rate. The maximal rate (Tmax) and half‐saturation constant (Km) of glucose transport from blood to brain were determined in rats by measuring the rate of blood‐to‐brain glucose transfer at different blood glucose concentrations. Each determination lasted 20 seconds. For whole‐brain, Tmax and Km averaged 258±33 (S.E.) μmol (100 g)‐1 min‐1 and 5.9±1.6 (S.E.) mmol 1‐1, respectively. The regional variations were insignificant. The new approach permits kinetic parameters to be measured locally in brain in rapidly changing functional states.

Original languageEnglish (US)
Pages (from-to)331-339
Number of pages9
JournalActa Physiologica Scandinavica
Volume108
Issue number4
DOIs
StatePublished - Apr 1980

Keywords

  • D‐glucose
  • blood‐brain barrier
  • facilitated diffusion
  • hyperglycemia
  • hypoglycemia

ASJC Scopus subject areas

  • Physiology

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