Rapid reversal of translational silencing: Emerging role of microRNA degradation pathways in neuronal plasticity

Research output: Contribution to journalReview articlepeer-review

Abstract

As microRNAs silence translation, rapid reversal of this process has emerged as an attractive mechanism for driving de novo protein synthesis mediating neuronal plasticity. Herein, we summarize recent studies identifying neuronal stimuli that trigger rapid decreases in microRNA levels and reverse translational silencing of plasticity transcripts. Although these findings indicate that neuronal stimulation elicits rapid degradation of selected microRNAs, we are only beginning to decipher the molecular pathways involved. Accordingly, we present an overview of several molecular pathways implicated in mediating microRNA degradation: Lin-28, translin/trax, and MCPIP1. As these degradation pathways target distinct subsets of microRNAs, they enable neurons to reverse silencing rapidly, yet selectively.

Original languageEnglish (US)
Pages (from-to)225-232
Number of pages8
JournalNeurobiology of Learning and Memory
Volume133
DOIs
StatePublished - Sep 1 2016

Keywords

  • Lin-28
  • MicroRNA
  • Plasticity
  • Pre-microRNA degradation
  • Silencing
  • Translin
  • Trax

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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