Rapid recurrence of Helicobacter pylori infection in Peruvian patients after successful eradication

Alberto Ramirez-Ramos, Robert H. Gilman, Raul Leon-Barua, Sixto Recavarren-Arce, Jose Watanabe, Guillermo Salazar, William Checkley, Jeff McDonald, Yanet Valdez, Luis Cordero, Juan Carrazco, Robert Berendson, Alicia Vasquez, Carlos Rodriguez, Juan Miyagi, Jose Bonilla, Maritza Alvarez, Vilma Gutierrez

Research output: Contribution to journalArticle

Abstract

Helicobacter pylori is associated with gastritis, peptic ulcer disease, and gastric cancer. Since gastric cancer is common in Peru, eradication of H. pylori may help to reduce the occurrence of gastric cancer. This study involved three randomized trials to determine the efficacy of four different triple-drug therapy regimens. The most successful regimen was furazolidone combined with bismuth subsalicylate and amoxicillin, which eradicated infection in 82% of patients. Patients successfully treated were followed every 2-3 months to determine the recurrence rate of H. pylori infection. Of 105 patients with H. pylori eradication documented by pathology and culture, 52% (55) returned for follow-up endoscopy, and in 73% (40) of these 55 the infection recurred during the 8-month follow-up period. Thirty-five patients from whom H. pylori was eradicated and who were tested for antibodies to H. pylori remained consistently seropositive. Rapid recurrence of H. pylori infection after successful eradication suggests that measures other than antimicrobial therapy are needed to fight H. pylori in developing countries.

Original languageEnglish (US)
Pages (from-to)1027-1031
Number of pages5
JournalClinical Infectious Diseases
Volume25
Issue number5
DOIs
StatePublished - Jan 1 1997

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Ramirez-Ramos, A., Gilman, R. H., Leon-Barua, R., Recavarren-Arce, S., Watanabe, J., Salazar, G., Checkley, W., McDonald, J., Valdez, Y., Cordero, L., Carrazco, J., Berendson, R., Vasquez, A., Rodriguez, C., Miyagi, J., Bonilla, J., Alvarez, M., & Gutierrez, V. (1997). Rapid recurrence of Helicobacter pylori infection in Peruvian patients after successful eradication. Clinical Infectious Diseases, 25(5), 1027-1031. https://doi.org/10.1086/516083