Rapid processing of the carboxyl terminus of a trypanosome variant surface glycoprotein

J. D. Bangs, D. Hereld, J. L. Krakow, G. W. Hart, P. T. Englund

Research output: Contribution to journalArticle

Abstract

The variant surface glycoprotein of the parasite Trypanosoma brucei contains a glycolipid of unknown structure covalently attached to its COOH terminus. We have shown, by using metabolic labeling with [35S]methionine or [3H]myristic acid, precipitation with specific antibodies, and NaDodSO4/polyacrylamide gel electrophoresis, that this glycolipid is attached to the variant surface glycoprotein polypeptide within 1 min after its translation.

Original languageEnglish (US)
Pages (from-to)3207-3211
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume82
Issue number10
DOIs
StatePublished - Sep 25 1985

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