Rapid monitoring of changes in water diffusion coefficients during reversible ischemia in cat and rat brain

D. Davis, J. Ulatowski, S. Eleff, M. Izuta, S. Mori, D. Shungu, P. C.M. van Zijl

Research output: Contribution to journalArticlepeer-review

Abstract

Changes in the diffusion constant of water during reversible brain ischemia and cardiac arrest were monitored with a 10‐s time resolution. Results (five cats, three rats) indicate that these changes are reversible and that the bulk of the changes are not caused by temperature or motion related to brain pulsations and blood flow. The rapid time course of the changes corresponds to the known time course for changes in energy state, signal transduction, and ionic homeostasis.

Original languageEnglish (US)
Pages (from-to)454-460
Number of pages7
JournalMagnetic resonance in medicine
Volume31
Issue number4
DOIs
StatePublished - Apr 1994

Keywords

  • NMR spectroscopy
  • cerebral blood flow
  • diffusion
  • ischemia‐reperfusion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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